A tumor microenvironments‐adapted polypeptide hydrogel/nanogel composite boosts antitumor molecularly targeted inhibition and immunoactivation
Z Li, W Xu, J Yang, J Wang, J Wang, G Zhu… - Advanced …, 2022 - Wiley Online Library
Various macro/microscopic biomaterials have been developed for controlled drug delivery in
the combination therapy of malignancies. However, uncertain loading ratio, release …
the combination therapy of malignancies. However, uncertain loading ratio, release …
[HTML][HTML] The role of angiogenesis in melanoma: Clinical treatments and future expectations
Z Wu, Y Bian, T Chu, Y Wang, S Man, Y Song… - Frontiers in …, 2022 - frontiersin.org
The incidence of melanoma has increased rapidly over the past few decades, with mortality
accounting for more than 75% of all skin cancers. The high metastatic potential of Melanoma …
accounting for more than 75% of all skin cancers. The high metastatic potential of Melanoma …
[HTML][HTML] Resistance mechanisms of anti-angiogenic therapy and exosomes-mediated revascularization in cancer
Anti-angiogenic therapies (AATs) have been widely used for cancer treatment. But the
beneficial effects of AATs are short, because AAT-induced tumor revascularization facilitates …
beneficial effects of AATs are short, because AAT-induced tumor revascularization facilitates …
[HTML][HTML] Suppression of PFKFB3-driven glycolysis restrains endothelial-to-mesenchymal transition and fibrotic response
H Zeng, T Pan, M Zhan, R Hailiwu, B Liu… - … and Targeted Therapy, 2022 - nature.com
Endothelial-to-mesenchymal transition (EndoMT), the process wherein endothelial cells lose
endothelial identity and adopt mesenchymal-like phenotypes, constitutes a critical …
endothelial identity and adopt mesenchymal-like phenotypes, constitutes a critical …
[HTML][HTML] IL-1RA inhibits esophageal carcinogenesis and lymphangiogenesis via downregulating VEGF-C and MMP9
Z Shen, P Zhang, W Zhang, F Luo, H Xu… - Functional & Integrative …, 2023 - Springer
Abstract Interleukin-1 receptor antagonist (IL-1RA) has been shown to play an important role
in cancer progression. However, its pathogenic effects and molecular mechanism in the …
in cancer progression. However, its pathogenic effects and molecular mechanism in the …
[HTML][HTML] Mechanistic insights and the clinical prospects of targeted therapies for glioblastoma: a comprehensive review
Glioblastoma (GBM) is a fatal brain tumour that is traditionally diagnosed based on
histological features. Recent molecular profiling studies have reshaped the World Health …
histological features. Recent molecular profiling studies have reshaped the World Health …
[HTML][HTML] Untargeted metabolomic analysis of ischemic injury in human umbilical vein endothelial cells reveals the involvement of arginine metabolism
R Wu, J Zhong, L Song, M Zhang, L Chen, L Zhang… - Nutrition & …, 2023 - Springer
Objective In this study, differentially expressed metabolites of vascular endothelial cells were
examined to further understand the metabolic regulation of ischemic injury by untargeted …
examined to further understand the metabolic regulation of ischemic injury by untargeted …
[HTML][HTML] Curcuminoids inhibit angiogenic behaviors of human umbilical vein endothelial cells via endoglin/smad1 signaling
Background: Angiogenesis is primarily attributed to the excessive proliferation and migration
of endothelial cells. Targeting the vascular endothelial growth factor (VEGF) is therefore …
of endothelial cells. Targeting the vascular endothelial growth factor (VEGF) is therefore …
Unveiling the Role of Tryptophan 2, 3-Dioxygenase in the Angiogenic Process
M Cecchi, C Anceschi, A Silvano, ML Coniglio… - Pharmaceuticals, 2024 - mdpi.com
Background: Indoleamine 2, 3-dioxygenase (IDO1) and tryptophan-2, 3-dioxygenase (TDO)
are the two principals enzymes involved in the catabolization of tryptophan (Trp) into …
are the two principals enzymes involved in the catabolization of tryptophan (Trp) into …
[HTML][HTML] Endoglin (CD105) and proliferation index in recurrent glioblastoma treated with anti-angiogenic therapy
AGP Bastos, B Carvalho, R Silva, D Leitão… - Frontiers in …, 2022 - frontiersin.org
CD105 is an angiogenic biomarker that is useful to determine the microvessel density (MVD)
within a tumour, namely in highly vascularized tumour like glioblastoma (GBM). However, its …
within a tumour, namely in highly vascularized tumour like glioblastoma (GBM). However, its …