New directions in the therapy of glioblastoma
K Szklener, M Mazurek, M Wieteska, M Wacławska… - Cancers, 2022 - mdpi.com
Simple Summary Despite the continuous development of treatment technology,
glioblastoma remains a challenge for modern medicine. The standard of care remains a …
glioblastoma remains a challenge for modern medicine. The standard of care remains a …
[HTML][HTML] Everything old is new again: drug repurposing approach for non-small cell lung cancer targeting MAPK signaling pathway
Non-small cell lung cancer (NSCLC) is a prominent subtype of lung carcinoma that accounts
for the majority of cancer-related deaths globally, and it is responsible for about 80% to 85 …
for the majority of cancer-related deaths globally, and it is responsible for about 80% to 85 …
DTSyn: a dual-transformer-based neural network to predict synergistic drug combinations
J Hu, J Gao, X Fang, Z Liu, F Wang… - Briefings in …, 2022 - academic.oup.com
Drug combination therapies are superior to monotherapy for cancer treatment in many ways.
Identifying novel drug combinations by screening is challenging for the wet-lab experiments …
Identifying novel drug combinations by screening is challenging for the wet-lab experiments …
Cathepsin B-responsive nanodrug delivery systems for precise diagnosis and targeted therapy of malignant tumors
Y Li, T Mei, S Han, T Han, Y Sun, H Zhang… - Chinese Chemical …, 2020 - Elsevier
The tumor microenvironment (TME) significantly influences cancer evolution and therapeutic
efficacy. Targeting biofunctional molecules to the TME has long been appreciated as a …
efficacy. Targeting biofunctional molecules to the TME has long been appreciated as a …
New directions and challenges in targeted therapies of advanced bladder cancer: the role of FGFR inhibitors
K Szklener, P Chmiel, A Michalski, S Mańdziuk - Cancers, 2022 - mdpi.com
Simple Summary The aim of this study was to present and analyze the up-to-date literature
describing the epidemiology, genetics, and histopathology of bladder cancer, as well as the …
describing the epidemiology, genetics, and histopathology of bladder cancer, as well as the …
The latest on uveal melanoma research and clinical trials: updates from the cure ocular melanoma (CURE OM) science meeting (2019)
Uveal melanoma is a rare cancer in adults, but its treatment is one of the clinical unmet
needs in the melanoma field. Metastatic disease develops in approximately 50% of patients …
needs in the melanoma field. Metastatic disease develops in approximately 50% of patients …
Biomaterial-assisted photoimmunotherapy for synergistic suppression of cancer progression
Y Li, J Cui, C Li, C Deng, G Deng, H Zhang… - Chinese Chemical …, 2023 - Elsevier
Photoimmunotherapy is an emerging treatment modality that uses photothermal,
photodynamic and photochemical processes to fight against cancer by eliciting a robust host …
photodynamic and photochemical processes to fight against cancer by eliciting a robust host …
[PDF][PDF] Methylglyoxal scavengers resensitize KRAS-mutated colorectal tumors to cetuximab
J Bellier, MJ Nokin, M Caprasse, A Tiamiou, A Blomme… - Cell reports, 2020 - cell.com
The use of cetuximab anti-epidermal growth factor receptor (anti-EGFR) antibodies has
opened the era of targeted and personalized therapy in colorectal cancer (CRC). Poor …
opened the era of targeted and personalized therapy in colorectal cancer (CRC). Poor …
[HTML][HTML] Protease-triggered bioresponsive drug delivery for the targeted theranostics of malignancy
Y Li, C Zhang, G Li, G Deng, H Zhang, Y Sun… - … Pharmaceutica Sinica B, 2021 - Elsevier
Proteases have a fundamental role in maintaining physiological homeostasis, but their
dysregulation results in severe activity imbalance and pathological conditions, including …
dysregulation results in severe activity imbalance and pathological conditions, including …
Loss of HAT1 expression confers BRAFV600E inhibitor resistance to melanoma cells by activating MAPK signaling via IGF1R
BRAF inhibitors (BRAFi) have been approved for the clinical treatment of BRAF-mutant
metastatic melanoma. Although initial responses to BRAFi are generally favorable, acquired …
metastatic melanoma. Although initial responses to BRAFi are generally favorable, acquired …