Heat shock proteins (HSPs) are a group of proteins, also known as molecular chaperones,
which participate in protein folding and maturation in response to stresses or high …

Abstract Heat Shock Factor 1 (HSF1) is a master regulator of heat shock responsive
signaling. In addition to playing critical roles in cellular heat shock response, emerging …

The ability of cancer cells to cope with stressful conditions is critical for their survival,
proliferation, and metastasis. The heat shock transcription factor 1 (HSF1) protects cells from …

Abstract Heat shock factor 1 (HSF1) systematically guards proteome stability and
proteostasis by regulating the expression of heat shock protein (HSP), thus rendering cancer …

Abstract The Heat Shock Response (HSR) is a cellular stress reaction crucial for cell survival
against stressors, including heat, in both healthy and cancer cells. Modulated electro …

Protein homeostasis, an important aspect of cellular fitness that encompasses the balance of
production, folding and degradation of proteins, has been linked to several diseases of the …

Prostate cancer (PCa) is the most frequently diagnosed cancer among men and the second
leading cause of death in Western countries. Clinically, screening drugs and develop …

Lung adenocarcinoma is one of the leading causes of cancer-related mortality globally.
Various treatment approaches and drugs had little influence on overall survival; thus, new …

Simple Summary Heat shock factor 1 (HSF1) is a transcription factor crucial for cellular
stress responses. HSF1 activates heat shock proteins (HSPs) in response to proteotoxic …

BH3 mimetics, including the BCL2/BCLXL/BCLw inhibitor navitoclax and MCL1 inhibitors
S64315 and tapotoclax, have undergone clinical testing for a variety of neoplasms. Because …