The antitumour activity of endogenous or adoptively transferred tumour-specific T cells is
highly dependent on their differentiation status. It is now apparent that less differentiated T …

Chimeric antigen receptor (CAR) T cells have achieved true clinical success in treating
hematological malignancy patients, laying the foundation of CAR T cells as a new pillar of …

Chimeric antigen receptor (CAR) T cell expansion and persistence emerged as key efficacy
determinants in cancer patients. These features are typical of early-memory T cells, which …

Metformin has been studied for its anticancer effects by regulating T cell functions. However,
the mechanisms through which metformin stimulates the differentiation of memory T cells …

Memory T cells include T memory stem cells (TSCM) and central memory T cells (TCM).
Compared with effector memory T cells (TEM) and effector T cells (TEFF), they have better …

Stem cell-like memory T cells (Tscm), are a newly defined memory T cell subset with
characteristics of long life span, consistent self-renewing, rapid differentiation into effector T …

T cell-based adoptive cell therapy (ACT) has exhibited excellent antitumoral efficacy
exemplified by the clinical breakthrough of chimeric antigen receptor therapy (CAR-T) in …

In recent years, treatment with chimeric antigen receptor (CAR) T-cells has revolutionized
the outcomes of patients with relapsed or refractory hematological malignancies with long …

Background Immune checkpoint inhibitors have achieved limited clinical effectiveness in
colon cancer. Stem memory T cells (TSCMs) and in-situ cytotoxic T cells are dominant …

Recently, accumulating evidence has elucidated the important role of T cells with stem-like
characteristics in long-term maintenance of T cell responses and better patient outcomes …