DNA double-strand breaks and inter-strand cross-links are the most harmful types of DNA
damage that cause genomic instability that lead to cancer development. The highest fidelity …

As the most frequent and vulnerable malignancy among women, breast cancer universally
manifests a formidable healthcare challenge. From a biological and molecular perspective, it …

Although surgical techniques and adjuvant therapies have undergone progressive
development for decades, the therapeutic outcomes for treating glioblastoma (GBM) remain …

DNA damage response (DDR) comprising DNA repair and cell-cycle checkpoint pathways,
is considered as a protective process that maintains the integrity of the genome. However …

Background Glioblastoma (GBM) is the most frequent type of primary brain cancer, having a
median survival of only 15 months. The current standard of care includes a combination of …

Breast cancer is a multifactorial, heterogeneous disease and the second most frequent
cancer amongst women worldwide. Metastasis is one of the most leading causes of death in …

Endometrial intraepithelial neoplasia (EIN), also known as endometrial atypical hyperplasia
(EAH) is believed to be the precursor lesion of endometrioid endometrial carcinoma (EEC) …

Purpose Advances in germline genetic testing have led to a surge in identification of ataxia-
telangiectasia mutated (ATM) variant carriers among breast cancer patients, raising …

Common variants of genes involved in DNA damage correction [tumor protein p53 (TP53),
murine double 2 homolog oncoprotein (MDM2) and ataxia‑telengiectasia mutated (ATM)] …

The HOX genes are a group of homeodomain-containing transcription factors that play
important regulatory roles in early development, including the establishment of cell and …