Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression
Z Li, H Zhang - Cellular and molecular life sciences, 2016 - Springer
Metabolic reprogramming is widely observed during cancer development to confer cancer
cells the ability to survive and proliferate, even under the stressed, such as nutrient-limiting …
cells the ability to survive and proliferate, even under the stressed, such as nutrient-limiting …
S-nitrosylation: an emerging paradigm of redox signaling
Nitric oxide (NO) is a highly reactive molecule, generated through metabolism of L-arginine
by NO synthase (NOS). Abnormal NO levels in mammalian cells are associated with multiple …
by NO synthase (NOS). Abnormal NO levels in mammalian cells are associated with multiple …
Systems analysis of intracellular pH vulnerabilities for cancer therapy
E Persi, M Duran-Frigola, M Damaghi… - Nature …, 2018 - nature.com
A reverse pH gradient is a hallmark of cancer metabolism, manifested by extracellular
acidosis and intracellular alkalization. While consequences of extracellular acidosis are …
acidosis and intracellular alkalization. While consequences of extracellular acidosis are …
GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain
Extracellular vesicles (EVs) are biological nanoparticles with important roles in intercellular
communication, and potential as drug delivery vehicles. Here we demonstrate a role for the …
communication, and potential as drug delivery vehicles. Here we demonstrate a role for the …
Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses
Multi‐omics datasets can provide molecular insights beyond the sum of individual omics.
Various tools have been recently developed to integrate such datasets, but there are limited …
Various tools have been recently developed to integrate such datasets, but there are limited …
[PDF][PDF] Glucose response by stem cell-derived β cells in vitro is inhibited by a bottleneck in glycolysis
Stem cell-derived β (SC-β) cells could provide unlimited human β cells toward a curative
diabetes treatment. Differentiation of SC-β cells yields transplantable islets that secrete …
diabetes treatment. Differentiation of SC-β cells yields transplantable islets that secrete …
Chaperone-mediated autophagy regulates adipocyte differentiation
Adipogenesis is a tightly orchestrated multistep process wherein preadipocytes differentiate
into adipocytes. The most studied aspect of adipogenesis is its transcriptional regulation …
into adipocytes. The most studied aspect of adipogenesis is its transcriptional regulation …
HSP90 molecular chaperones, metabolic rewiring, and epigenetics: impact on tumor progression and perspective for anticancer therapy
Heat shock protein 90 (HSP90) molecular chaperones are a family of ubiquitous proteins
participating in several cellular functions through the regulation of folding and/or assembly of …
participating in several cellular functions through the regulation of folding and/or assembly of …
Regulation of autophagy by nuclear GAPDH and its aggregates in cancer and neurodegenerative disorders
G Butera, N Mullappilly, F Masetto, M Palmieri… - International Journal of …, 2019 - mdpi.com
Several studies indicate that the cytosolic enzyme glyceraldehyde-3-phosphate
dehydrogenase (GAPDH) has pleiotropic functions independent of its canonical role in …
dehydrogenase (GAPDH) has pleiotropic functions independent of its canonical role in …
[PDF][PDF] Secreted pyruvate kinase M2 promotes lung cancer metastasis through activating the integrin Beta1/FAK signaling pathway
C Wang, S Zhang, J Liu, Y Tian, B Ma, S Xu, Y Fu… - Cell reports, 2020 - cell.com
Cancer cell-derived secretomes have been documented to play critical roles in cancer
progression. Intriguingly, alternative extracellular roles of intracellular proteins are involved …
progression. Intriguingly, alternative extracellular roles of intracellular proteins are involved …
