Melanoma is one of the most immunogenic tumors and its relationship with host immune
system is currently under investigation. Many immunomodulatory mechanisms, favoring …

Many advances in the treatment of cancer have been driven by the development of targeted
therapies that inhibit oncogenic signaling pathways and tumor-associated angiogenesis, as …

Simple Summary Malignant melanoma is more dangerous than most other skin cancers due
to its ability to spread early and aggressively. Until the development of new therapeutic …

Methods One-hundred and seventy patients with advanced NSCLC were explored. Paraffin-
embedded tumour sections were stained with PD-L1 antibody. EGFR mutation was …

Cutaneous malignant melanoma is the fastest growing and the most aggressive form of skin
cancer that is diagnosed. However, its incidence is relatively scarce compared to the highest …

The occurrence and development of cancer are closely related to the immune escape of
tumor cells and immune tolerance. Unlike previous surgical, chemotherapy, radiotherapy …

Despite recent advances in tumor treatment through cancer immunotherapy, the efficacy of
this approach remains to be improved. Looking forward to high rates of objective clinical …

Simple Summary Cutaneous Melanoma (CM), arising from pigment-producing melanocytes
in the skin, is an aggressive cancer with high metastatic potential. While cutaneous …

Initially understood for its physiological maintenance of self-tolerance, the immune
checkpoint molecule has recently been recognized as a promising anti-cancer target. There …

The interaction of programmed cell death-1 and its ligand is widely studied in cancer.
Monoclonal antibodies blocking these molecules have had great success but little is known …