BACKGROUND Novel methods in predicting survival in patients with spinal metastases may
help guide clinical decision-making and stratify treatments regarding surgery vs palliative …

Background The completion of the human genome project and the accomplished milestones
in the human proteome project; as well as the progress made so far in computational …

Malignancy of the pancreas is a leading cause of cancer-related mortality, with the highest
case-fatality of all cancers. Nevertheless, the lack of sensitive biomarkers and presence of …

Abstract Human carboxylesterase-2 (CES2) and cytochrome P450 3A4 (CYP3A4) are two
major drug metabolizing enzymes that play critical roles in hydrolytic and oxidative …

Background: Triple negative breast cancer (TNBC) is high-risk due to its rapid drug
resistance and recurrence, metastasis, and lack of targeted therapy. So far, no molecularly …

DNA-binding compounds are of extraordinary importance in medicine, accounting for a
substantial portion of antitumor drugs in clinical usage. However, their mechanisms of action …

Cancer is one of the deadliest diseases with a cure far from being found. Despite the
extraordinary advances in the therapy approaches, only a few patients respond to …

Personalized medicine is a relatively new and interesting concept in the medical and
healthcare industries. New approaches in current research have supported the search for …

In fields such as biomedicine, neural networks may encounter a problem known as
underspecification, in which models learn a solution that performs poorly and inconsistently …

Purpose: To understand the translational trajectory of genomic tests in cancer screening,
diagnosis, prognosis, and treatment, we reviewed tests that have been assessed by …