[HTML][HTML] microRNA therapeutics in cancer—an emerging concept

MY Shah, A Ferrajoli, AK Sood, G Lopez-Berestein… - …, 2016 - thelancet.com
MicroRNAs (miRNAs) are an evolutionarily conserved class of small, regulatory non-coding
RNAs that negatively regulate protein coding gene and other non-coding transcripts …

[HTML][HTML] Control of immunoregulatory molecules by miRNAs in T cell activation

A Rodríguez-Galán, L Fernández-Messina… - Frontiers in …, 2018 - frontiersin.org
MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This
mechanism boosts or dampens immune functions to preserve homeostasis while supporting …

MicroRNAs: Key modulators of inflammation-associated diseases

B Chatterjee, M Sarkar, S Bose, MT Alam… - Seminars in Cell & …, 2024 - Elsevier
Inflammation is a multifaceted biological and pathophysiological response to injuries,
infections, toxins, and inflammatory mechanisms that plays a central role in the progression …

[HTML][HTML] Differential expression of miRNA regulates T cell differentiation and plasticity during visceral leishmaniasis infection

RK Pandey, S Sundar, VK Prajapati - Frontiers in microbiology, 2016 - frontiersin.org
Visceral leishmaniasis (VL) is a tropical neglected disease caused by Leishmania donovani,
results in significant mortality in the Indian subcontinent. The plasticity of T cell proliferation …

MicroRNAs as regulators and effectors of hematopoietic transcription factors

MJ Kim, CI Civin, TJ Kingsbury - Wiley Interdisciplinary Reviews …, 2019 - Wiley Online Library
Hematopoiesis is a highly‐regulated development process orchestrated by lineage‐specific
transcription factors that direct the generation of all mature blood cells types, including red …

The role of microRNAs in the control of innate immune response in cancer

S Jasinski-Bergner, O Mandelboim… - Journal of the National …, 2014 - academic.oup.com
Ligands for receptors of natural killer (NK) cells and CD8+ cytotoxic T lymphocytes (CTL),
such as the inhibitory nonclassical HLA-G, the activating stress-induced major …

Epigenetics in T-cell driven inflammation and cancer

L Falkowski, J Buddenkotte, A Datsi - Seminars in Cell & Developmental …, 2024 - Elsevier
For decades, scientists have been investigating how processes such as gene expression,
stem cell plasticity, and cell differentiation can be modulated. The discovery of epigenetics …

Cyanidin-3-O-glucoside attenuates lipopolysaccharide-induced inflammation in human corneal epithelial cells by inducing Let-7b-5p-mediated HMGA2/PI3K/Akt …

X Li, M Sun, Y Long - Inflammation, 2020 - Springer
The bacterial keratitis causes viability loss and apoptosis in the corneal epithelial cells
(CECs). The cyanidin-3-O-glucoside (C3G) benefits visual system and also possess anti …

Distinct microRNA profiles for complete hydatidiform moles at risk of malignant progression

LH Lin, I Maestá, JDS Laurent, KT Hasselblatt… - American Journal of …, 2021 - Elsevier
Background MicroRNAs are small noncoding RNAs with important regulatory functions.
Although well-studied in cancer, little is known about the role of microRNAs in premalignant …

[HTML][HTML] A novel panel of differentially-expressed microRNAs in breast cancer brain metastasis may predict patient survival

A Giannoudis, K Clarke, R Zakaria, D Varešlija… - Scientific Reports, 2019 - nature.com
Breast cancer brain metastasis (BCBM) is an area of unmet clinical need. MicroRNAs
(miRNAs) have been linked to the metastatic process in breast cancer (BC). In this study, we …