Salivary gland hypofunction and xerostomia in head and neck radiation patients

SB Jensen, A Vissink, KH Limesand… - JNCI …, 2019 - academic.oup.com
Background The most manifest long-term consequences of radiation therapy in the head
and neck cancer patient are salivary gland hypofunction and a sensation of oral dryness …

Current ideas to reduce or salvage radiation damage to salivary glands

A Vissink, P Van Luijk, JA Langendijk… - Oral diseases, 2015 - Wiley Online Library
Radiation‐induced hyposalivation is still a major problem after radiotherapy for head and
neck cancer. Current and promising new thoughts to reduce or salvage radiation damage to …

[HTML][HTML] The significance of the dysregulation of canonical Wnt signaling in head and neck squamous cell carcinomas

J Paluszczak - Cells, 2020 - mdpi.com
The knowledge about the molecular alterations which are found in head and neck
squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are …

[PDF][PDF] PERIOD 2 regulates low-dose radioprotection via PER2/pGSK3β/β-catenin/Per2 loop

AT Alexandrou, Y Duan, S Xu, C Tepper, M Fan, J Tang… - Iscience, 2022 - cell.com
During evolution, humans are acclimatized to the stresses of natural radiation and circadian
rhythmicity. Radiosensitivity of mammalian cells varies in the circadian period and adaptive …

[HTML][HTML] Mechanism, prevention, and treatment of radiation-induced salivary gland injury related to oxidative stress

Z Liu, L Dong, Z Zheng, S Liu, S Gong, L Meng, Y Xin… - Antioxidants, 2021 - mdpi.com
Radiation therapy is a common treatment for head and neck cancers. However, because of
the presence of nerve structures (brain stem, spinal cord, and brachial plexus), salivary …

[HTML][HTML] Chronic exposure of humans to high level natural background radiation leads to robust expression of protective stress response proteins

S Nishad, PK Chauhan, R Sowdhamini, A Ghosh - Scientific Reports, 2021 - nature.com
Understanding exposures to low doses of ionizing radiation are relevant since most
environmental, diagnostic radiology and occupational exposures lie in this region. However …

Identification of novel NRAGE involved in the radioresistance of esophageal cancer cells

H Zhou, G Zhang, X Xue, Y Yang, Y Yang, X Chang… - Tumor Biology, 2016 - Springer
Radiotherapy (RT) is one main method for the treatment of esophageal squamous cell
carcinoma (ESCC), and the radioresistance is the predominant cause of patients with local …

[HTML][HTML] Fractionated head and neck irradiation impacts taste progenitors, differentiated taste cells, and Wnt/β-catenin signaling in adult mice

D Gaillard, LA Shechtman, SE Millar, LA Barlow - Scientific Reports, 2019 - nature.com
Head and neck cancer patients receiving conventional repeated, low dose radiotherapy
(fractionated IR) suffer from taste dysfunction that can persist for months and often years after …

Licl promotes recovery of radiation-induced oral mucositis and dysgeusia

J Zhu, H Zhang, J Li, X Zheng, X Jia… - Journal of Dental …, 2021 - journals.sagepub.com
Oral mucositis and taste dysfunction are frequently complained by patients with head and
neck cancer receiving radiotherapy, challenging the clinical outcome of cancer treatment …

Cigarette smoking promotes cancer-related transformation of oral epithelial cells through activation of Wnt and MAPK pathway

R Sarkar, A Das, RR Paul, A Barui - Future Oncology, 2019 - Future Medicine
Aim: Study aims to investigate the effect of cigarette smoking on cancer-related
transformation in oral epithelial cells of smokers through evaluating the alteration in Wnt/β …