Metastasis is a crucial hallmark of cancer progression, which involves numerous factors
including the degradation of the extracellular matrix (ECM), the epithelial-to-mesenchymal …

MicroRNAs (miRNAs) are endogenous 22 nt non-coding RNAs that target mRNAs for
cleavage or translational repression. Numerous miRNAs regulate programmed cell death …

Osteosarcoma (OS) is the most common type of primary bone tumor in children and
adolescents and has been associated with a high degree of malignancy, early metastasis, rapid …

Hypoxia occurs naturally at high-altitudes and pathologically in hypoxic solid tumors. Here,
we report that genes involved in various human cancers evolved rapidly in Tibetans and six …

Long noncoding RNAs (lncRNAs) are a class of non-protein-coding molecules longer than
200 nucleotides that are involved in the development and progression of many types of …

Circular RNAs (circRNAs) are newly discovered endogenous non-coding RNAs featuring
structural stability, high abundance, and tissue-specific expression. CircRNAs are prevalent …

Osteosarcoma is the most common primary malignant bone tumor; its standard treatment
includes neoadjuvant chemotherapy combined with surgery. Neoadjuvant chemotherapy has …

Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. They are
traditionally considered to be cholesterol-lowering agents, but in recent years more and more …

Pathologic fractures of the femur because of bone metastases seriously affect the quality of
life of cancer patients. Different surgical options are indicated to achieve a durable and solid …

Distant metastasis is the main cause of death for cancer patients. Recently, the newly
discovered programmed cell death includes necroptosis, pyroptosis, and ferroptosis, which …