Genome-wide association studies have identified thousands of loci for common diseases,
but, for the majority of these, the mechanisms underlying disease susceptibility remain …

Understanding the functional consequences of genetic variation, and how it affects complex
human disease and quantitative traits, remains a critical challenge for biomedicine. We …

Accurate prediction of the functional effect of genetic variation is critical for clinical genome
interpretation. We systematically characterized the transcriptome effects of protein-truncating …

Molecular medical research on aromatherapy has been steadily increasing for use as an
adjuvant therapy in managing psychiatric disorders and to examine its therapeutic mechanisms…

The {Mn 4 O 5 Ca} cluster of photosystem II is a well-known cubane-like transition-metal (TM)
cluster that plays important roles in solar energy conversion. The artificial synthesis of …

The selection of a scoring matrix and gap penalty parameters continues to be an important
problem in sequence alignment. We describe here an algorithm, the 'Bayes block aligner, …

Osteosarcoma is a malignant tumor derived from primitive osteogenic mesenchymal cells,
which is extremely harmful to the human body and has a high mortality rate. Early diagnosis …

Histopathological examination is an important criterion in the clinical diagnosis of osteosarcoma.
With the improvement of hardware technology and computing power, pathological …

Bone malignant tumors are metastatic and aggressive, with poor treatment outcomes and
prognosis. Rapid and accurate diagnosis is crucial for limb salvage and increasing the survival …

Studies of the relationship between DNA variation and gene expression variation, often
referred to as “expression quantitative trait loci (eQTL) mapping”, have been conducted in many …