User profiles for Zhou Zhu
 | Zhou ZhuBrown University Verified email at brown.edu Cited by 26401 |
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
…, A Shahab, EA Sekinger, A Yang, Z Moqtaderi, Z Zhu… - nature, 2007 - nature.com
We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Interleukin 17 (IL-17) has been linked to autoimmune diseases, although its regulation and
function have remained unclear. Here we have evaluated in vitro and in vivo the …
function have remained unclear. Here we have evaluated in vitro and in vivo the …
[HTML][HTML] Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
Z Zhu, RJ Homer, Z Wang, Q Chen… - The Journal of …, 1999 - Am Soc Clin Investig
Interleukin (IL)-13 is a pleiotropic cytokine produced in large quantities by activated CD4 +
Th2 lymphocytes. To define further its potential in vivo effector functions, the Clara cell 10-kDa …
Th2 lymphocytes. To define further its potential in vivo effector functions, the Clara cell 10-kDa …
Assessing computational tools for the discovery of transcription factor binding sites
The prediction of regulatory elements is a problem where computational methods offer great
hope. Over the past few years, numerous tools have become available for this task. The …
hope. Over the past few years, numerous tools have become available for this task. The …
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
Asthma is an increasingly common disease that remains poorly understood and difficult to
manage. This disease is characterized by airway hyperreactivity (AHR, defined by …
manage. This disease is characterized by airway hyperreactivity (AHR, defined by …
Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1
Interleukin (IL)-13 is a key mediator of tissue fibrosis caused by T helper cell type 2
inflammation. We hypothesized that the fibrogenic effects of IL-13 are mediated by transforming …
inflammation. We hypothesized that the fibrogenic effects of IL-13 are mediated by transforming …
Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation
Chitin is a surface component of parasites and insects, and chitinases are induced in lower
life forms during infections with these agents. Although chitin itself does not exist in humans, …
life forms during infections with these agents. Although chitin itself does not exist in humans, …
Regulation of inflammatory responses by IL-17F
…, YH Wang, KS Schluns, RR Broaddus, Z Zhu… - The Journal of …, 2008 - rupress.org
Although interleukin (IL) 17 has been extensively characterized, the function of IL-17F, which
has an expression pattern regulated similarly to IL-17, is poorly understood. We show that …
has an expression pattern regulated similarly to IL-17, is poorly understood. We show that …
[HTML][HTML] Airway remodeling in asthma
Asthma is estimated to affect 15 million people in the United States. After declining in the
1970s, its prevalence, morbidity, and mortality have increased since the 1980s. It now affects 1 …
1970s, its prevalence, morbidity, and mortality have increased since the 1980s. It now affects 1 …
[HTML][HTML] Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase–and cathepsin-dependent emphysema
Cigarette smoke exposure is the major cause of chronic obstructive pulmonary disease (COPD).
However, only a minority of smokers develop significant COPD, and patients with …
However, only a minority of smokers develop significant COPD, and patients with …
