Acute AMPK activation exacerbates ischemic brain damage experimentally. Paradoxically,
the clinical use of an AMPK activator metformin reduces the incidence of stroke. We …

Cerebral ischemia induces massive mitochondrial damage. These damaged mitochondria
are cleared, thus attenuating brain injury, by mitophagy. Here, we identified the involvement …

Mitochondrial dysfunction plays important roles in Parkinson's disease (PD) and the degradation
of the damaged mitochondria by the mitochondria quality control system is important for …

It has long been believed that the lysosome is an important digestive organelle. There is
increasing evidence that the lysosome is also involved in pathogenesis of a variety of …

Mitophagy, the elimination of damaged mitochondria through autophagy, promotes neuronal
survival in cerebral ischemia. Previous studies found deficient mitophagy in ischemic …

Malignant gliomas represent the majority of primary brain tumors. The current standard
treatments for malignant gliomas include surgical resection, radiation therapy, and chemotherapy…

Prompt reperfusion after cerebral ischemia is critical for neuronal survival. Any strategies that
extend the limited reperfusion window will be of great importance. Acidic postconditioning (…

A pivotal role for excitotoxicity in neurodegenerative diseases is gaining increasingly more
acceptance, but the underlying mechanisms through which it participates in …

Neurotoxins generally inhibit or promote the release of neurotransmitters or bind to receptors
that are located in the pre- or post-synaptic membranes, thereby affecting physiological …

Despite of similarities between glioma stem/progenitor cells (GSPCs) and neural stem/progenitor
cells (NSPCs), inhibition of differentiation is a distinct characteristic of GSPCs. In this …