The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity
Z Wang, JC Gorski, MA Hamman… - Clinical …, 2001 - Wiley Online Library
Background St John's wort(Hypericum perforatum) is a popular over‐the‐counter dietary
supplement and herbal remedy that has been implicated in drug interactions with substrates of …
supplement and herbal remedy that has been implicated in drug interactions with substrates of …
The interaction between St John's wort and an oral contraceptive
SD Hall, Z Wang, SM Huang… - Clinical …, 2003 - Wiley Online Library
Objectives The popular herbal remedy St John's wort is an inducer of cytochrome P450 (CYP)
3A enzymes and may reduce the efficacy of oral contraceptives. Therefore we evaluated …
3A enzymes and may reduce the efficacy of oral contraceptives. Therefore we evaluated …
Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans
Aims Cytochrome P450 2E1 (CYP2E1) is thought to activate a number of protoxins, and has
been implicated in the development of liver disease. Increased hepatic expression of …
been implicated in the development of liver disease. Increased hepatic expression of …
Effect of St John's wort on the pharmacokinetics of fexofenadine
Z Wang, MA Hamman, SM Huang… - Clinical …, 2002 - Wiley Online Library
Background St John's wort is a popular over‐the‐counter dietary supplement and herbal
remedy that has been implicated in drug interactions with several substrates of P‐glycoprotein. …
remedy that has been implicated in drug interactions with several substrates of P‐glycoprotein. …
Focal adhesion kinase (FAK) inhibition synergizes with KRAS G12C inhibitors in treating cancer through the regulation of the FAK–YAP signaling
…, Y Zhang, J Zhang, P Liu, B Jiao, Z Wang… - Advanced …, 2021 - Wiley Online Library
KRAS mutation is one of the most prevalent genetic drivers of cancer development, yet
KRAS mutations are until very recently considered undruggable. There are ongoing trials of …
KRAS mutations are until very recently considered undruggable. There are ongoing trials of …
The effect of short‐and long‐term administration of verapamil on the disposition of cytochrome P450 3A and P‐glycoprotein substrates
GL Lemma, Z Wang, MA Hamman… - Clinical …, 2006 - Wiley Online Library
Background Verapamil has the capability to inhibit and induce cytochrome P450 (CYP) 3A
and P‐glycoprotein (P‐gp), but the relative extent and time course of these events in vivo are …
and P‐glycoprotein (P‐gp), but the relative extent and time course of these events in vivo are …
[HTML][HTML] Inhibition of focal adhesion kinase enhances antitumor response of radiation therapy in pancreatic cancer through CD8+ T cells
… support, including Molly Lutrey, Dwayne Thomas, Junke Wang, David Choi and Xingyi Pan.
… Yanan Liu and Zaiqi Wang are employees of InxMed. Zaiqi Wang is a shareholder of InxMed…
… Yanan Liu and Zaiqi Wang are employees of InxMed. Zaiqi Wang is a shareholder of InxMed…
Efficacy and safety of elbasvir/grazoprevir in participants with hepatitis C virus genotype 1, 4, or 6 infection from the Asia–Pacific region and Russia: final results from …
L Wei, JD Jia, FS Wang, JQ Niu… - Journal of …, 2019 - Wiley Online Library
Background and Aim Although treatment with direct‐acting antivirals has dramatically improved
morbidity and mortality attributable to chronic hepatitis C virus infection, universal access …
morbidity and mortality attributable to chronic hepatitis C virus infection, universal access …
[HTML][HTML] Synergism of FAK and ROS1 inhibitors in the treatment of CDH1-deficient cancers mediated by FAK-YAP signaling
…, Y Yao, C Liu, X Xie, D Li, P Liu, Z Wang… - … journal of biological …, 2023 - ncbi.nlm.nih.gov
CDH1 deficiency is common in diffuse gastric cancer and triple negative breast cancer patients,
both of which still lack effective therapeutics. ROS1 inhibition results in synthetic lethality …
both of which still lack effective therapeutics. ROS1 inhibition results in synthetic lethality …
Desloratadine dose selection in children aged 6 months to 2 years: comparison of population pharmacokinetics between children and adults
…, B Kantesaria, C Banfield, Z Wang - British journal of clinical …, 2007 - Wiley Online Library
What is already known about this subject • According to recent literature, the pathophysiologies
of allergic rhinitis and chronic idiopathic urticaria are thought to be similar in adults and …
of allergic rhinitis and chronic idiopathic urticaria are thought to be similar in adults and …