Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer
featured with high intra-tumoral heterogeneity and poor prognosis. To comprehensively …

Therapy that targets programmed death 1 or programmed death 1 ligand 1 (PD-1/PD-L1),
which are known as immune checkpoints, has been recently rapidly developing as …

Genome-wide sequencing technologies have led to the identification of many non-coding
RNAs and revealed an important role for these molecules in cancer. Although there have been …

Pancreatic cancer is an extremely dismal malignance. Chemotherapy has been widely
applied to treat this intractable tumor. It has exclusive tumor microenvironment (TME), …

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related
deaths. Deregulation of cell-cycle control is thought to be a crucial event in malignant …

Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …

Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early
diagnosis and metastasis. The tumor microenvironment induced by interactions between …

Pancreatic cancer is a malignancy with poor prognosis and high mortality. The recent
increase in pancreatic cancer incidence and mortality has resulted in an increased number of …

DNA modifications such as 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)
are epigenetic marks known to affect global gene expression in mammals. Given their …

Pancreatic cancer is currently one of the most lethal diseases. In recent years, increasing
evidence has shown that reprogrammed metabolism may play a critical role in the …