User profiles for Yunhua Liu

Yunhua Liu

PhytoAB Bioscience Inc
Verified email at sagc.org.cn
Cited by 1792

TP53 loss creates therapeutic vulnerability in colorectal cancer

Y Liu, X Zhang, C Han, G Wan, X Huang, C Ivan… - Nature, 2015 - nature.com
TP53, a well-known tumour suppressor gene that encodes p53, is frequently inactivated by
mutation or deletion in most human tumours 1 , 2 . A tremendous effort has been made to …

A Histone Acetyltransferase Regulates Active DNA Demethylation in Arabidopsis

W Qian, D Miki, H Zhang, Y Liu, X Zhang, K Tang… - Science, 2012 - science.org
Active DNA demethylation is an important part of epigenetic regulation in plants and animals.
How active DNA demethylation is regulated and its relationship with histone modification …

Economies of scale, plot size, human capital, and productivity in Chinese agriculture

BM Fleisher, Y Liu - Quarterly Review of Economics and Finance, 1992 - go.gale.com
The authors test hypotheses on economies of scale, diseconomies of multiple plots, and
multiple crops and derive estimates of their impact on total factor productivity and the marginal …

Genome-wide identification and analysis of drought-responsive microRNAs in Oryza sativa

L Zhou, Y Liu, Z Liu, D Kong, M Duan… - Journal of experimental …, 2010 - academic.oup.com
In addition to regulating growth and development, the most important function of microRNAs
(miRNAs) in plants is the regulation of a variety of cellular processes underlying plant …

Tet-mediated formation of 5-hydroxymethylcytosine in RNA

…, N Zhong, NJ Amato, Y Liu, S Liu… - Journal of the …, 2014 - ACS Publications
Oxidation of 5-methylcytosine in DNA by ten-eleven translocation (Tet) family of enzymes
has been demonstrated to play a significant role in epigenetic regulation in mammals. We …

Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway

G Wan, R Mathur, X Hu, Y Liu, X Zhang, G Peng, X Lu - Cellular signalling, 2013 - Elsevier
The maintenance of genome integrity is essential for the proper function and survival of all
organisms. Human cells have evolved prompt and efficient DNA damage response to …

A novel non‐coding RNA lncRNA‐JADE connects DNA damage signalling to histone H4 acetylation

G Wan, X Hu, Y Liu, C Han, AK Sood, GA Calin… - The EMBO …, 2013 - embopress.org
A prompt and efficient DNA damage response (DDR) eliminates the detrimental effects of
DNA lesions in eukaryotic cells. Basic and preclinical studies suggest that the DDR is one of …

[HTML][HTML] Transcriptomic and metabolomic studies disclose key metabolism pathways contributing to well-maintained photosynthesis under the drought and the …

X Ma, H Xia, Y Liu, H Wei, X Zheng, C Song… - Frontiers in Plant …, 2016 - frontiersin.org
In contrast to wild species, drought-tolerance in crops requires a fully functional metabolism
during drought (particularly photosynthetic processes). However, the link between drought-…

Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer

J Xu, Y Liu, Y Li, H Wang, S Stewart… - Nature …, 2019 - nature.com
TP53 is the most frequently mutated or deleted gene in triple negative breast cancer (TNBC).
Both the loss of TP53 and the lack of targeted therapy are significantly correlated with poor …

High-throughput acoustofluidic fabrication of tumor spheroids

B Chen, Y Wu, Z Ao, H Cai, A Nunez, Y Liu, J Foley… - Lab on a Chip, 2019 - pubs.rsc.org
Three-dimensional (3D) culture of multicellular spheroids, offering a desirable biomimetic
microenvironment, is appropriate for recapitulating tissue cellular adhesive complexity and …