The viral E2 gene product plays a crucial role in the human papillomavirus (HPV) vegetative
cycle by regulating both transcription and replication of the viral genome. E2 is a …

Genomic alterations in different types of cancer have been identified by comprehensive
sequencing methodologies, revealing TP53 as the most frequently mutated gene across the …

Two classes of Human papillomaviruses (HPV) infect the anogenital track: high risk viruses
that are associated with risk of cervical cancer and low risk types that drive development of …

We have previously shown that proteasome inhibitor bortezomib stabilizes p53 in stem and
progenitor cells within gastrointestinal tissues. Here, we characterize the effect of bortezomib …

The productive human papillomavirus (HPV) life cycle is tightly linked to the differentiation
and cycling of keratinocytes. Deregulation of these processes and stimulation of cell …

The large number of mutations identified across all cancers represents an untapped
reservoir of targets that can be useful for therapeutic targeting if highly selective, mutation-specific …

These findings show that bortezomib is less active in p53-defective tumors, yet its success in
treating multiple myeloma suggests its use can be extended to p53-proficient solid tumors. …

All-hydrocarbon, i, i+7 stapled peptide inhibitors of the p53-Mdm2 interaction have emerged
as promising new leads for cancer therapy. Typical chemical synthesis via olefin metathesis …

The circadian clock regulates daily rhythms of numerous physiological activities through
tightly coordinated modulation of gene expression and biochemical functions. Circadian …

Integration of the viral DNA in the cellular genome has been suggested to be critical in
carcinogenic progression of HPV-associated cervical neoplasia. This event can be accompanied …