Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway

L Peng, YL Ran, H Hu, L Yu, Q Liu, Z Zhou… - …, 2009 - academic.oup.com
The purpose of this study was to investigate invasion- and metastasis-related genes in gastric
cancer. To this end, we used the transwell system to select a highly invasive subcell line …

[HTML][HTML] Enolase 1 regulates stem cell-like properties in gastric cancer cells by stimulating glycolysis

…, LX Sun, L Yu, J Liu, LC Sun, ZH Yang, YL Ran - Cell death & …, 2020 - nature.com
Recent studies have demonstrated that gastric cancer stem cells (CSCs) are a rare sub-group
of gastric cancer (GC) cells and have an important role in promoting the tumor growth and …

[HTML][HTML] BCAT1 activates PI3K/AKT/mTOR pathway and contributes to the angiogenesis and tumorigenicity of gastric cancer

…, L Yu, J Liu, LC Sun, ZH Yang, YL Ran… - Frontiers in Cell and …, 2021 - frontiersin.org
Background Focusing on antiangiogenesis may provide promising choices for treatment of
gastric cancer (GC). This study aimed to investigate the mechanistic role of BCAT1 in the …

TM4SF3 promotes esophageal carcinoma metastasis via upregulating ADAM12m expression

Z Zhou, YL Ran, H Hu, J Pan, ZF Li, LZ Chen… - Clinical & experimental …, 2008 - Springer
Esophageal cancer is characterized by rapid clinical progression and poor prognosis due to
adjacent tissue invasion and distant organs metastasis at a very early stage. TM4SF3 (…

[HTML][HTML] MYH9 is crucial for stem cell-like properties in non-small cell lung cancer by activating mTOR signaling

…, L Yu, J Liu, LC Sun, ZH Yang, X Shu, YL Ran - Cell Death …, 2021 - nature.com
The fatality rate of non-small cell lung cancer (NSCLC) has been high due to the existence
of cancer stem cells (CSCs). Non-muscle myosin heavy chain 9 (MYH9) can promote the …

[HTML][HTML] HSP90, as a functional target antigen of a mAb 11C9, promotes stemness and tumor progression in hepatocellular carcinoma

…, L Yu, J Liu, LC Sun, ZH Yang, X Shu, YL Ran - Stem Cell Research & …, 2023 - Springer
Background Identification of promising targeted antigens that exhibited cancer-specific
expression is a crucial step in the development of novel antibody-targeted therapies. We here …

[HTML][HTML] Alpha-enolase (ENO1), identified as an antigen to monoclonal antibody 12C7, promotes the self-renewal and malignant phenotype of lung cancer stem cells …

…, L Yu, LX Sun, ZH Yang, CA Wu, YL Ran - Stem Cell Research & …, 2021 - Springer
Background Tumor-associated antigens (TAAs) can be targeted in cancer therapy. We
previously identified a monoclonal antibody (mAb) 12C7, which presented anti-tumor activity in …

Palladin promotes cancer stem cell‐like properties in lung cancer by activating Wnt/Β‐Catenin signaling

…, SY Liu, L Yu, LX Sun, LC Sun, YL Ran - Cancer …, 2023 - Wiley Online Library
Background Cancer stem cells (CSCs) are responsible for drug resistance, cancer relapse,
and metastasis. Here, we report the first analysis of Palladin expression and its impacts on …

Overexpressed Derlin-1 inhibits ER expansion in the endothelial cells derived from human hepatic cavernous hemangioma

D Hu, YL Ran, X Zhong, H Hu, L Yu, JN Lou, LX Sun… - BMB …, 2006 - koreascience.kr
Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be targeted
for refolding or degradation to maintain the homeostasis of the ER. Derlin-1 was reportedly …

Coherently parallel fiber-optic distributed acoustic sensing using dual Kerr soliton microcombs

…, YP Liang, H Zhang, GF Yan, LM Ma, ZL Ran… - Science …, 2024 - science.org
Fiber-optic distributed acoustic sensing (DAS) has proven to be a revolutionary technology
for the detection of seismic and acoustic waves with ultralarge scale and ultrahigh sensitivity, …