The multiple roles of Id-1 in cancer progression

MT Ling, X Wang, X Zhang, YC Wong - Differentiation, 2006 - Elsevier
Id-1 (Inhibitor of differentiation/DNA binding) is a member of the helix–loop–helix protein
family expressed in actively proliferating cells. It regulates gene transcription by …

Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target

…, KW Chan, FL Chan, C Glackin, YC Wong, X Wang - Cancer research, 2005 - AACR
Androgen-independent metastatic prostate cancer is the main obstacle in the treatment of this
cancer. Unlike a majority of solid cancers, prostate cancer usually shows poor response to …

Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition

…, AP Yuen, MT Ling, WK Kwok, XH Wang, YC Wong… - Clinical cancer …, 2006 - AACR
Purpose: Hepatocellular carcinoma (HCC) is a rapidly growing tumor associated with a high
propensity for vascular invasion and metastasis. Epithelial-mesenchymal transition (EMT) is …

Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells

X Wang, MT Ling, XY Guan, SW Tsao, HW Cheung… - Oncogene, 2004 - nature.com
Taxol is one of the widely used chemotherapeutic drugs against many types of human cancer.
While it is considered as one of the most effective anticancer drugs, treatment failure often …

S‐allylcysteine, a water‐soluble garlic derivative, suppresses the growth of a human androgen‐independent prostate cancer xenograft, CWR22R, under in vivo …

…, DTW Lee, SW Tsao, X Wang, YC Wong - BJU …, 2007 - Wiley Online Library
OBJECTIVE To evaluate the effect of S‐allylcysteine (SAC) on CWR22R, a human androgen‐independent
(AI) prostate cancer xenograft, in nude mice. Despite extensive research …

[HTML][HTML] γ-Tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways

…, HY Han, DTW Lee, MT Ling, YC Wong… - British journal of …, 2008 - nature.com
Tocotrienol-rich fraction (TRF) has demonstrated antiproliferative effect on prostate cancer (PCa)
cells. To elucidate this anticancer property in PCa cells, this study aimed, first, to identify …

Id-1 expression promotes cell survival through activation of NF-κB signalling pathway in prostate cancer cells

…, X Wang, XS Ouyang, K Xu, SW Tsao, YC Wong - Oncogene, 2003 - nature.com
The growth-promoting effect of Id-1 (inhibitor of differentiation/DNA binding) has been
demonstrated in a number of human cancers. However, the mechanisms responsible for its action …

Id‐1 promotes tumorigenicity and metastasis of human esophageal cancer cells through activation of PI3K/AKT signaling pathway

…, YY Li, X Wang, MT Ling, YC Wong… - … journal of cancer, 2009 - Wiley Online Library
Id‐1 (inhibitor of differentiation or DNA binding) is a helix‐loop‐helix protein that is overexpressed
in many types of cancer including esophageal squamous cell carcinoma (ESCC). We …

Liver transplantation in rats using small-for-size grafts: a study of hemodynamic and morphological changes

…, IOL Ng, YC Wong, LF Qin, ST Fan, J Wong - Archives of …, 2001 - jamanetwork.com
Background Damage to a small-for-size liver graft after reperfusion is frequently observed but
the mechanism of injury remains unclear. Hypothesis Injury to a small-for-size liver graft is …

Overexpression of Id-1 in prostate cancer cells promotes angiogenesis through the activation of vascular endothelial growth factor (VEGF)

…, WK Kwok, Q Wang, X Wang, YC Wong - …, 2005 - academic.oup.com
Androgen-independent metastatic prostate cancer is the main cause of cancer related
death in men. One of the reasons for this is the lack of understanding of the molecular …