Leukocytes accumulate at sites of inflammation and microbial infection in direct response to
locally produced chemotactic factors, which signal through specific G protein-coupled …

Chemokines are a superfamily of small proteins that bind to G protein-coupled receptors on
target cells and were originally discovered as mediators of directional migration of immune …

FPR and FPRL1 belong to the seven-transmembrane, G protein-coupled chemoattractant
receptor superfamily. Because of their capacity to interact with bacterial chemotactic …

Amyloid ß (Aß) is a major contributor to the pathogenesis of Alzheimer’s disease (AD). Although
Aß has been reported to be directly neurotoxic, it also causes indirect neuronal damage …

Alzheimer’s disease (AD) is characterized by overproduction of β amyloid peptides in the
brain with progressive loss of neuronal cells. The 42-aa form of the β amyloid peptide (Aβ 42) …

Background Inflammatory responses in the CNS mediated by activated glial cells play an
important role in host-defense but are also involved in the development of neurodegenerative …

Alzheimer's disease (AD) is characterized by amyloid plaques and neurofibrillary tangles
associated with chronic inflammation. APPswe/PS1dE9 is an AD mouse model bearing mutant …

Resistin is an adipokine that was independently identified by three groups. Kim et al. identified
resistin as an adipose tissue-specific secreted factor by microarray analysis (1). Holcomb …

Trp-Lys-Tyr-Val-d-Met (WKYMVm) is a synthetic leukocyte-activating peptide postulated to
use seven-transmembrane, G protein-coupled receptor (s). In the study to characterize the …

Toll-like receptors (TLRs) belong to pattern-recognition receptor family that could recognize
exogenous pathogen-associated molecular patterns and endogenous damage-associated …