Angiotensin-converting enzyme (ACE) enhances the proliferation and migration of pulmonary
artery smooth muscle cells (PASMCs), which contribute to the pathogenesis of hypoxic …

The kinesin family member 14 (KIF14) is a potential oncogene and is involved in the
metastasis of various cancers. Nevertheless, its function in gastric cancer (GC) remains poorly …

The risk assessment methods of agricultural supply chain finance (SCF) are explored to
reduce agricultural SCF’s credit risks. First, the genetic algorithm (GA) is utilized to adjust and …

Sentrin/SUMO (small ubiquitin-like modifier)-specific proteases (SENPs) have been implicated
in the development of prostate cancer. However, due to the low abundance of SUMO-…

Multiple myeloma is a malignant plasma-cell disease, which is highly dependent on the
hypoxic bone marrow microenvironment. However, the underlying mechanisms of hypoxia …

SUMO-specific protease 1 (SENP1), a member of the de-SUMOylation protease family, is
elevated in prostate cancer (PCa) cells and is involved in PCa pathogenesis. Momordin Ιc (Mc)…

T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive leukemia that is primarily
caused by aberrant activation of the NOTCH1 signaling pathway. Recent studies have …

Metastasis is major cause of mortality in patients with ovarian cancer. MiR-373 has been
shown to play pivotal roles in tumorigenesis and metastasis; however, a role for miR-373 in …

Secondary mutations of FLT3 have become the main mechanism of FLT3 inhibitor
resistance that presents a significant clinical challenge. Herein, a series of pyrazole-3-amine …

As the best-characterized ubiquitin-like protein (UBL), small ubiquitin-related modifier (SUMO)
was found to conjugate with a number of proteins to regulate cellular functions including …