Although links between cancer and inflammation were firstly proposed in the nineteenth
century, the molecular mechanism has not yet been clearly understood. Epidemiological studies …

… Wu, Renfang Mao and Yihui Fan generated the data and wrote the … and Yihui Fan initiated
the study and revised the manuscript. Zhiwei Fan, Changyue Wu, Renfang Mao and Yihui Fan …

RNA-binding proteins (RBPs) are central players in post-transcriptional regulation and immune
homeostasis. The ribonuclease and RBP Regnase-1 exerts critical roles in both immune …

The ubiquitin system regulates virtually all aspects of cellular function. We report a method
to target the myriad enzymes that govern ubiquitination of protein substrates. We used …

Transforming growth factor-β-activated kinase 1 (TAK1) plays an essential role in the tumor
necrosis factor α (TNFα)- and interleukin-1β (IL-1β)-induced IκB kinase (IKK)/nuclear factor-…

Lys63-linked polyubiquitination of RIG-I is essential in antiviral immune defense, yet the
molecular mechanism that negatively regulates this critical step is poorly understood. Here, we …

Glucocorticoid-induced TNFR-related protein (GITR) is a costimulatory molecule with diverse
effects on effector T cells and regulatory T cells (Tregs), but the underlying mechanism …

IκBα serves as a central anchoring molecule in the sequestration of NF-κB transcription factor
in the cytoplasm. Ubiquitination-mediated IκBα degradation immediately precedes and is …

CD4 + T cells orchestrate immune responses and destruction of allogeneic organ transplants,
but how this process is regulated on a transcriptional level remains unclear. Here, we …

Although dysfunctional circadian clock has emerged as a hallmark of cancer, fundamental
gaps remain in our understanding of the underlying mechanisms involved. Here, we …