We demonstrate directed differentiation of telencephalic precursors from mouse embryonic
stem (ES) cells using optimized serum-free suspension culture (SFEB culture). Treatment …

Objective Soluble oligomers of amyloid β (Aβ), rather than amyloid fibrils, have been proposed
to initiate synaptic and cognitive dysfunction in Alzheimer's disease (AD). However, there …

Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a disease characterized
by chronic, profound, disabling, and unexplained fatigue. Although it is hypothesized that …

Fever is triggered by an elevation of prostaglandin E 2 (PGE 2 ) in the brain. However, the
mechanism of its elevation remains unanswered. We herein cloned the rat glutathione-…

Fatigue is defined as a decline in the ability and efficiency of mental and/or physical activities
that is caused by excessive mental and/or physical activities. Fatigue can be classified as …

We previously showed that intraperitoneal injection of lipopolysaccharide induced
cyclooxygenase-2 (COX-2) mRNA in as yet unidentified cells of blood vessels and leptomeninges in …

The purpose of this study was to determine the safety, distribution, internal dosimetry, and
initial human epidermal growth factor receptor 2 (HER2)–positive tumor images of 64 Cu-…

Background It is known that chronic fatigue is associated with sympathetic hyperactivity.
However, the relationship between autonomic function and mental fatigue caused by a …

OBJECTIVE: This study examined the effects of coenzyme Q10 administration on physical
fatigue. METHODS: In a double-blinded, placebo-controlled, three crossover design, 17 …

Oxidative stress is implicated in the pathogenesis of neuronal degenerative diseases. Oxidative
stress has been shown to activate extracellular signal-regulated kinases (ERK)1/2. We …