Introduction: Adenocarcinoma is the most common histologic type of lung cancer. To
address advances in oncology, molecular biology, pathology, radiology, and surgery of lung …

Recently it has been reported that mutations in the tyrosine kinase domain of the epidermal
growth factor receptor(EGFR) gene occur in a subset of patients with lung cancer showing a …

Purpose To evaluate the relationship between mutations of the epidermal growth factor
receptor (EGFR) gene and the effectiveness of gefitinib treatment in patients with recurrent lung …

Background Patients with non-small-cell lung cancer harbouring mutations in the epidermal
growth factor receptor (EGFR) gene respond well to the EGFR-specific tyrosine kinase …

In this study, we report for the first time reduced expression of the let-7 microRNA in human
lung cancers. Interestingly, 143 lung cancer cases that had undergone potentially curative …

We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest
human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 …

Purpose: Non–small cell lung cancers carrying activating mutations in the gene for the
epidermal growth factor receptor (EGFR) are highly sensitive to EGFR-specific tyrosine kinase …

The 2015 World Health Organization (WHO) Classification of Tumors of the Lung, Pleura,
Thymus and Heart has just been published with numerous important changes from the 2004 …

MicroRNAs (miRNAs) are small noncoding RNAs, thought to be involved in physiologic and
developmental processes by negatively regulating expression of target genes. We have …

<p id="p001">The EML4 (echinoderm microtubule-associated protein-like 4)–ALK (anaplastic
lymphoma kinase) fusion-type tyrosine kinase is an oncoprotein found in 4 to 5% of non–…