Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation
The cytochrome P450 (CYP) epoxygenase enzymes CYP2J and CYP2C catalyze the epoxidation
of arachidonic acid to epoxyeicosatrienoic acids (EETs), which are rapidly hydrolyzed …
of arachidonic acid to epoxyeicosatrienoic acids (EETs), which are rapidly hydrolyzed …
[HTML][HTML] Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice
Cytochrome P-450 (CYP)-derived epoxyeicosatrienoic acids (EETs) possess potent anti-inflammatory
effects in vitro. However, the effect of increased CYP-mediated EET biosynthesis …
effects in vitro. However, the effect of increased CYP-mediated EET biosynthesis …
Activation of the acute inflammatory response alters cytochrome P450 expression and eicosanoid metabolism
KN Theken, Y Deng, MA Kannon, TM Miller… - Drug metabolism and …, 2011 - ASPET
Cytochrome P450 (P450)-mediated metabolism of arachidonic acid regulates inflammation
in hepatic and extrahepatic tissue. CYP2C/CYP2J-derived epoxyeicosatrienoic and …
in hepatic and extrahepatic tissue. CYP2C/CYP2J-derived epoxyeicosatrienoic and …
[HTML][HTML] IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis
…, AS Volmer, H Dang, Y Deng… - The Journal of …, 2019 - Am Soc Clin Investig
Cystic fibrosis (CF) lung disease is characterized by early and persistent mucus accumulation
and neutrophilic inflammation in the distal airways. Identification of the factors in CF …
and neutrophilic inflammation in the distal airways. Identification of the factors in CF …
Cardiomyocyte‐specific role of miR‐24 in promoting cell survival
Cardiomyocyte cell death is a major contributing factor to various cardiovascular diseases
and is therefore an important target for the design of therapeutic strategies. More recently, …
and is therefore an important target for the design of therapeutic strategies. More recently, …
The modulatory effects of the volatile oil of ginger on the cellular immune response in vitro and in vivo in mice
H Zhou, Y Deng, Q Xie - Journal of ethnopharmacology, 2006 - Elsevier
The aim of this study was to investigate the immunomodulatory effects of the volatile oil of
ginger (Zingiber officinale Roscoe) in vitro and in vivo in mice. In vitro, the volatile oil of ginger (…
ginger (Zingiber officinale Roscoe) in vitro and in vivo in mice. In vitro, the volatile oil of ginger (…
Enalapril reverses high-fat diet-induced alterations in cytochrome P450-mediated eicosanoid metabolism
KN Theken, Y Deng, RN Schuck… - American Journal …, 2012 - journals.physiology.org
Metabolism of arachidonic acid by cytochrome P450 (CYP) to biologically active eicosanoids
has been recognized increasingly as an integral mediator in the pathogenesis of …
has been recognized increasingly as an integral mediator in the pathogenesis of …
Chemo-and radio-protective effects of polysaccharide of Spirulina platensis on hemopoietic system of mice and dogs.
HQ Zhang, AP Lin, Y Sun, YM Deng - Acta Pharmacologica Sinica, 2001 - europepmc.org
Aim To observe polysaccharide of Spirulina platensis (PSp) on the hematopoietic system of
mouse and dogs which were damaged by injection of cyclophosphamide (CTX) and 60Co-…
mouse and dogs which were damaged by injection of cyclophosphamide (CTX) and 60Co-…
[HTML][HTML] Metformin treatment does not inhibit growth of pancreatic cancer patient-derived xenografts
MB Lipner, R Marayati, Y Deng, X Wang, L Raftery… - PloS one, 2016 - journals.plos.org
There is currently tremendous interest in developing anti-cancer therapeutics targeting cell
signaling pathways important for both cancer cell metabolism and growth. Several …
signaling pathways important for both cancer cell metabolism and growth. Several …
RETRACTED: TGF-β1 induces alveolar epithelial to mesenchymal transition in vitro
HW Yao, QM Xie, JQ Chen, YM Deng, HF Tang - 2004 - Elsevier
The aim of this study was to investigate whether transforming growth factor-β1 (TGF-β1) could
induce alveolar epithelial to mesenchymal transition (EMT) in vitro. Alveolar epithelial cells …
induce alveolar epithelial to mesenchymal transition (EMT) in vitro. Alveolar epithelial cells …