User profiles for Xun Lan
 | Xun LanAssociate Professor at Tsinghua University Verified email at tsinghua.edu.cn Cited by 4174 |
iEnhancer-2L: a two-layer predictor for identifying enhancers and their strength by pseudo k-tuple nucleotide composition
Motivation: Enhancers are of short regulatory DNA elements. They can be bound with proteins
(activators) to activate transcription of a gene, and hence play a critical role in promoting …
(activators) to activate transcription of a gene, and hence play a critical role in promoting …
Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth
…, C Chen, BSJ Bian, L Zhang, L Chen, X Lan… - Nature …, 2017 - nature.com
Intense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth of
glioblastoma (GBM), but the underlying mechanisms remain undefined. Herein, we report …
glioblastoma (GBM), but the underlying mechanisms remain undefined. Herein, we report …
Integration of Hi-C and ChIP-seq data reveals distinct types of chromatin linkages
We have analyzed publicly available K562 Hi-C data, which enable genome-wide unbiased
capturing of chromatin interactions, using a Mixture Poisson Regression Model and a power…
capturing of chromatin interactions, using a Mixture Poisson Regression Model and a power…
Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2
The pandemic of COVID-19, caused by SARS-CoV-2, is a major global health threat.
Epidemiological studies suggest that bats (Rhinolophus affinis) are the natural zoonotic reservoir …
Epidemiological studies suggest that bats (Rhinolophus affinis) are the natural zoonotic reservoir …
Methylation QTLs are associated with coordinated changes in transcription factor binding, histone modifications, and gene expression levels
DNA methylation is an important epigenetic regulator of gene expression. Recent studies
have revealed widespread associations between genetic variation and methylation levels. …
have revealed widespread associations between genetic variation and methylation levels. …
iDNA-Prot| dis: identifying DNA-binding proteins by incorporating amino acid distance-pairs and reduced alphabet profile into the general pseudo amino acid …
Playing crucial roles in various cellular processes, such as recognition of specific nucleotide
sequences, regulation of transcription, and regulation of gene expression, DNA-binding …
sequences, regulation of transcription, and regulation of gene expression, DNA-binding …
Caffeine protects against MPTP‐induced blood‐brain barrier dysfunction in mouse striatum
X Chen, X Lan, I Roche, R Liu… - Journal of …, 2008 - Wiley Online Library
The blood‐brain barrier (BBB) is important physiologically. Pathologically, BBB disruption
has been implicated in a wide spectrum of neurological disorders including Parkinson’s …
has been implicated in a wide spectrum of neurological disorders including Parkinson’s …
scRNA-seq of gastric tumor shows complex intercellular interaction with an alternative T cell exhaustion trajectory
…, W Kang, L Jia, J Xiong, H Hu, Y Tian, X Lan - Nature …, 2022 - nature.com
The tumor microenvironment (TME) in gastric cancer (GC) has been shown to be important
for tumor control but the specific characteristics for GC are not fully appreciated. We …
for tumor control but the specific characteristics for GC are not fully appreciated. We …
An immune-related gene signature for predicting survival and immunotherapy efficacy in hepatocellular carcinoma
Background Hepatocellular carcinoma (HCC) ranks the fourth in terms of cancer-related
mortality globally. Herein, in this research, we attempted to develop a novel immune-related …
mortality globally. Herein, in this research, we attempted to develop a novel immune-related …
[PDF][PDF] Large-scale clonal analysis resolves aging of the mouse hematopoietic stem cell compartment
Aging is linked to functional deterioration and hematological diseases. The hematopoietic
system is maintained by hematopoietic stem cells (HSCs), and dysfunction within the HSC …
system is maintained by hematopoietic stem cells (HSCs), and dysfunction within the HSC …
