Climate is widely recognised as an important determinant of the latitudinal diversity gradient.
However, most existing studies make no distinction between direct and indirect effects of …

Aim Biological invasions threaten biodiversity globally. Large‐scale studies of non‐native
plant species invasiveness typically focus on identifying ecological differences between …

Blockade of the immune checkpoint PD-1/PD-L1 with monoclonal antibodies demonstrated
unprecedented clinical efficacies in many cancers. But the orally available low molecular …

Arbuscular mycorrhizal (AM) and ectomycorrhizal (EcM) associations are critical for host-tree
performance. However, how mycorrhizal associations correlate with the latitudinal tree beta-…

PD-1 and CTLA-4 antibodies offer great hope for cancer immunotherapy. However, many
patients are incapable of responding to PD-1 and CTLA-4 blockade and show low response …

Although immune checkpoint inhibition has been shown to effectively activate antitumor
immunity in various tumor types, only a small subset of patients can benefit from PD-1/PD-L1 …

Background Aside from immune checkpoint inhibitors targeting programmed cell death protein
1 (PD-1) and programmed death ligand 1 (PD-L1), intervention of CD47/Sirpα mediated ‘…

Dendritic cells (DCs) can process the antigens of cancer vaccine and thus stimulate the CD8+
T cells to recognize and kill the tumor cells that express these antigens. However, lack of …

Metformin is a widely used antidiabetic drug for cancer prevention and treatment. However,
the overproduction of lactic acid and its inefficiency in cancer therapy limit its application. …

Aim The Tibetan Plateau harbours the highest alpine and endemic plant diversity in the
world, attributed to rapid diversification during the plateau uplift and Quaternary climate …