[HTML][HTML] SARS-CoV-2 Nsp5 activates NF-κB pathway by upregulating SUMOylation of MAVS

…, Q Peng, Y Liu, S Hu, W Liu, S Li, X Shu… - Frontiers in …, 2021 - frontiersin.org
The COVID-19 is an infectious disease caused by SARS-CoV-2 infection. A large number of
clinical studies found high-level expression of pro-inflammatory cytokines in patients …

Bacteroides Fragilis in the gut microbiomes of Alzheimer's disease activates microglia and triggers pathogenesis in neuronal C/EBPβ transgenic mice

…, AM Alam, JP Haran, BA McCormick, X Shu… - Nature …, 2023 - nature.com
Gut dysbiosis contributes to Alzheimer’s disease (AD) pathogenesis, and Bacteroides
strains are selectively elevated in AD gut microbiota. However, it remains unknown which …

Cleavage of GSK‐3β by calpain counteracts the inhibitory effect of Ser9 phosphorylation on GSK‐3β activity induced by H2O2

Y Feng, Y Xia, G Yu, X Shu, H Ge, K Zeng… - Journal of …, 2013 - Wiley Online Library
Glycogen synthase kinase‐3 beta (GSK‐3β) dysfunction may play an essential role in the
pathogenesis of psychiatric, metabolic, neurodegenerative diseases, in which oxidative stress …

[HTML][HTML] Codonopsis pilosula polysaccharide attenuates Aβ toxicity and cognitive defects in APP/PS1 mice

…, D Ke, Q Wang, R Liu, JZ Wang, X Shu… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Codonopsis pilosula Polysaccharides (CPPs), a traditional Chinese medicine used for
thousands of years, is a potential neuroprotective polysaccharide via a relatively poorly …

Gut microbiota mediated the individualized efficacy of Temozolomide via immunomodulation in glioma

…, Y Deng, H Wang, J Liu, J Qiao, W Liu, X Shu… - Journal of Translational …, 2023 - Springer
Background Temozolomide (TMZ) is the preferred chemotherapy strategy for glioma therapy.
As a second-generation alkylating agent, TMZ provides superior oral bio-availability. …

A novel PCR–DGGE-based method for identifying plankton 16S rDNA for the diagnosis of drowning

F He, D Huang, L Liu, X Shu, H Yin, X Li - Forensic science international, 2008 - Elsevier
The diagnosis of drowning is one of the most difficult issues in forensic practice. We have
developed a sensitive and specific PCR and DGGE method for identifying the 16S rDNA of …

SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination

HB Luo, YY Xia, XJ Shu, ZC Liu… - Proceedings of the …, 2014 - National Acad Sciences
Intracellular accumulation of the abnormally modified tau is hallmark pathology of Alzheimer’s
disease (AD), but the mechanism leading to tau aggregation is not fully characterized. …

[HTML][HTML] ω-3PUFAs improve cognitive impairments through Ser133 phosphorylation of CREB upregulating BDNF/TrkB signal in schizophrenia

…, K Zeng, Y Xia, D Ke, R Liu, JZ Wang, H Shen, X Shu… - …, 2020 - Elsevier
Schizophrenia (SZ) is a serious mental condition and is associated with cognitive
impairments. Brain-derived neurotrophic factor (BDNF) is one of the learning- and memory-related …

PM2.5 exposure‐induced ferroptosis in neuronal cells via inhibiting ERK/CREB pathway

…, C Xu, B Ma, W Liu, B Sun, Q Ru, X Shu - Environmental …, 2022 - Wiley Online Library
PM 2.5 exposure has been demonstrated to correlate with neurological disorders recently.
Ferroptosis is recognized as a newly found programmed form of cell death associated with …

Current and further outlook on the protective potential of Antrodia camphorata against neurological disorders

…, J Qiao, Y Liu, Q Peng, Z Zhang, X Shu… - Frontiers in …, 2024 - frontiersin.org
Prevalent neurological disorders such as Alzheimer’s disease, Parkinson’s disease, and
stroke are increasingly becoming a global burden as society ages. It is well-known that …