Design of a novel chimeric peptide via dual blockade of CD47/SIRPα and PD-1/PD-L1 for cancer immunotherapy

…, R Xu, D Zheng, X Yang, S Li, X Zhou, X Niu… - Science China Life …, 2023 - Springer
Although immune checkpoint inhibition has been shown to effectively activate antitumor
immunity in various tumor types, only a small subset of patients can benefit from PD-1/PD-L1 …

Neoadjuvant chemotherapy followed by concurrent chemoradiation for locoregionally advanced nasopharyngeal carcinoma: interim results from 2 prospective phase …

L Kong, C Hu, X Niu, Y Zhang, Y Guo, IWK Tham… - Cancer, 2013 - Wiley Online Library
BACKGROUND The authors studied the efficacy of neoadjuvant chemotherapy, consisting
of a taxane, cisplatin, and 5‐fluorouracil (5‐FU) (the TPF regimen) followed by concurrent …

Identification of a novel small-molecule inhibitor targeting TIM-3 for cancer immunotherapy

…, A Wu, X Zhang, Y Li, B Li, S Jin, Q Dong, X Niu… - Biochemical …, 2023 - Elsevier
PD-1/PD-L1 blockade has achieved substantial clinical results in cancer treatment. However,
the expression of other immune checkpoints leads to resistance and hinders the efficacy of …

Experience with combination of cetuximab plus intensity-modulated radiotherapy with or without chemotherapy for locoregionally advanced nasopharyngeal …

X Niu, C Hu, L Kong - Journal of cancer research and clinical oncology, 2013 - Springer
Purpose To evaluate the safety and efficacy of cetuximab plus intensity-modulated radiotherapy
(IMRT) with or without chemotherapy for locoregionally advanced nasopharyngeal …

β-Catenin is important for cancer stem cell generation and tumorigenic activity in nasopharyngeal carcinoma

R Jiang, X Niu, Y Huang, X Wang - Acta Biochim Biophys Sin, 2016 - academic.oup.com
Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors with poor
prognosis and recurrence in South China. The hard eradication of NPC in clinic is …

[HTML][HTML] Peptide drugs: a new direction in cancer immunotherapy

X Sui, X Niu, X Zhou, Y Gao - Cancer Biology & Medicine, 2024 - ncbi.nlm.nih.gov
Cancer immunotherapy has emerged as a promising approach in cancer treatment and is
considered a major advancement after surgical interventions, radiotherapy, chemotherapy, …

[HTML][HTML] Long-term outcomes of nasopharyngeal carcinoma patients with T1-2 stage in intensity-modulated radiotherapy era

X Niu, F Xue, P Liu, C Hu, X He - International Journal of Medical …, 2022 - ncbi.nlm.nih.gov
Objectives: To evaluate long-term outcomes and late toxicities of nasopharyngeal carcinoma
(NPC) patients with T1-2N0-3M0 stage in intensity-modulated radiotherapy (IMRT) era. …

[HTML][HTML] Predictive single nucleotide polymorphism markers for acute oral mucositis in patients with nasopharyngeal carcinoma treated with radiotherapy

Z Le, X Niu, Y Chen, X Ou, G Zhao, Q Liu, W Tu, C Hu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The aim of this study was to investigate the association between the susceptibility of severe
oral mucositis (OM) in Chinese nasopharyngeal carcinoma (NPC) patients treated with …

[HTML][HTML] Identification and optimization of peptide inhibitors to block VISTA/PSGL-1 interaction for cancer immunotherapy

X Niu, M Wu, G Li, X Zhou, W Cao, W Zhai, A Wu… - … Pharmaceutica Sinica B, 2023 - Elsevier
Developing new therapeutic agents for cancer immunotherapy is highly demanding due to
the low response ratio of PD-1/PD-L1 blockade in cancer patients. Here, we discovered that …

Fish oil-based microemulsion can efficiently deliver oral peptide blocking PD-1/PD-L1 and simultaneously induce ferroptosis for cancer immunotherapy

…, W Li, S Li, S Chen, Z Hu, Z He, X Zhu, X Niu… - Journal of Controlled …, 2024 - Elsevier
Peptide immune checkpoint inhibitors in cancer immunotherapy have attracted great attention
recently, but oral delivery of these peptides remains a huge challenge due to the harsh …