De novo and acquired resistance, which are largely attributed to genetic alterations, are
barriers to effective anti-epidermal-growth-factor-receptor (EGFR) therapy. To generate …

Background MicroRNAs (miRNAs) are important regulators that play key roles in tumorigenesis
and tumor progression. A previous report has shown that let-7 family members can act …

Epigenetic changes play significant roles in the development of cancer. UHRF1, as an
epigenetic regulator, has been shown to be overexpressed and to coordinate tumor suppressor …

Following dramatic success in many types of advanced solid tumors, interest in
immunotherapy for the treatment of colorectal cancer (CRC) is increasingly growing. Given the …

Background Epithelial-to-mesenchymal transition (EMT) is a process linked to metastasis
and drug resistance with non-coding RNAs (ncRNAs) playing pivotal roles. We previously …

The evolutionarily conserved target-of-rapamycin (TOR) kinase coordinates cellular and
organismal growth in all eukaryotes. Amino acids (AAs) are key upstream signals for …

Metastasis is a major clinical obstacle responsible for the high mortality and poor prognosis
of gastric cancer (GC). MicroRNAs (miRNAs) are critical mediators of metastasis that act by …

The evolutionarily conserved target of rapamycin (TOR) kinase acts as a master regulator
that coordinates cell proliferation and growth by integrating nutrient, energy, hormone and …

Background Gastric cancer (GC) is one of the most common malignancies worldwide,
particularly in China. DNA damage‐inducible transcript 4 (DDIT4) is a mammalian target of …

Background Loss of cell-cell adhesion is important for the development of cancer invasion
and metastasis. Vinculin, a key adhesion-related protein, can affect metastasis and prognosis …