Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure
during cancer treatment. Bypassing the apoptotic pathway to induce cancer cell death is …

Introduction: Pancreatic cancer has the worst survival rate of all cancers. The current
standard care for metastatic pancreatic cancer is gemcitabine, however, the success of this …

In recent years, cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has
achieved considerable success in the clinic. However, ICIs are significantly limited by the fact …

Pancreatic ductal adenocarcinoma (PDAC) constitutes one of the most challenging lethal
tumors and has a very poor prognosis. In addition to cancer cells, the tumor microenvironment …

Genome-wide association studies have identified several loci associated with pancreatic
cancer risk; however, the mechanisms by which genetic factors influence the development of …

Pancreatic cancer has the lowest survival rate among human cancers, and there are no
effective markers for its screening and early diagnosis. To identify genetic susceptibility markers …

Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin,
phenotypic and functional heterogeneity, are the most essential components of the tumor …

Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes, …

Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …