Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes, …

Simple Summary The immunosuppressive microenvironment is closely related to the poor
prognosis of patients with PDAC. Tfh cells play an anti-tumor function in various malignant …

Identification of neddylation and ubiquitination pathways that regulate MEN1 protein stability
provides an opportunity for therapeutic interventions for treating patients with pancreatic …

Background Previously, we uncovered a patient subgroup with highly malignant pancreatic
cancer with serum markers CEA + /CA125 + /CA19-9 ≥ 1000 U/mL (triple-positive, TP). …

The neuroendocrine neoplasm, in general, refers to a heterogeneous group of all tumors
originating from peptidergic neurons and neuroendocrine cells. Neuroendocrine neoplasms …

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are a group of rare tumors
that are increasing in prevalence. The complex tumor immune microenvironment (TIME) …

Purpose: The systemic inflammation response index (SIRI), based on peripheral neutrophil,
monocyte, and lymphocyte counts, was recently emerged and used as a novel tool in …

BACKGROUND Systemic inflammation and nutrition status play an important role in cancer
metastasis. The combined index of hemoglobin, albumin, lymphocyte, and platelet (HALP), …

Purpose This study was designed to assess the computed tomography maximum (CTmax)
value on pretherapeutic arterial phase computed tomography (APCT) images to predict …

Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with poor prognosis.
Many preoperative biomarkers can predict postoperative survival of PDAC patients. In this …