Advanced glycation end products in foods and a practical guide to their reduction in the diet

J Uribarri, S Woodruff, S Goodman, W Cai… - Journal of the American …, 2010 - Elsevier
Modern diets are largely heat-processed and as a result contain high levels of advanced
glycation end products (AGEs). Dietary advanced glycation end products (dAGEs) are known to …

Advanced glycoxidation end products in commonly consumed foods

T Goldberg, W Cai, M Peppa, V Dardaine… - Journal of the American …, 2004 - Elsevier
OBJECTIVE: Advanced glycoxidation end products (AGEs), the derivatives of glucose-protein
or glucose-lipid interactions, are implicated in the complications of diabetes and aging. …

Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy

H Vlassara, W Cai, J Crandall… - Proceedings of the …, 2002 - National Acad Sciences
Diet is a major environmental source of proinflammatory AGEs (heat-generated advanced
glycation end products); its impact in humans remains unclear. We explored the effects of two …

Diet‐derived advanced glycation end products are major contributors to the body's AGE pool and induce inflammation in healthy subjects

J Uribarri, W Cai, O Sandu, M Peppa… - Annals of the New …, 2005 - Wiley Online Library
Advanced glycation end products (AGEs) are a heterogeneous group of compounds that
form continuously in the body. Their rate of endogenous formation is markedly increased in …

Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging

J Uribarri, W Cai, M Peppa, S Goodman… - The Journals of …, 2007 - academic.oup.com
Background. Oxidative stress (OS) and inflammatory mediators increase with aging. The levels
of advanced glycation endproducts (AGEs), prooxidant factors linked to chronic diseases …

Restriction of dietary glycotoxins reduces excessive advanced glycation end products in renal failure patients

J Uribarri, M Peppa, W Cai, T Goldberg… - Journal of the …, 2003 - journals.lww.com
ABSTRACT. Advanced glycation endproduct (AGE) levels are elevated in renal failure
patients and may contribute to the excessive cardiovascular disease in this population. Diet-…

Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1

J Uribarri, W Cai, M Ramdas, S Goodman… - Diabetes …, 2011 - Am Diabetes Assoc
OBJECTIVE Increased oxidative stress (OS) and impaired anti-OS defenses are important
in the development and persistence of insulin resistance (IR). Several anti-inflammatory and …

Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1

W Cai, M Ramdas, L Zhu, X Chen… - Proceedings of the …, 2012 - National Acad Sciences
The epidemics of insulin resistance (IR) and type 2 diabetes (T2D) affect the first world as
well as less-developed countries, and now affect children as well. Persistently elevated …

Improved Insulin Sensitivity Is Associated With Restricted Intake of Dietary Glycoxidation Products in the db/db Mouse

SM Hofmann, HJ Dong, Z Li, W Cai, J Altomonte… - Diabetes, 2002 - Am Diabetes Assoc
Advanced glycation end products (AGEs), known promoters of diabetic complications, form
abundantly in heated foods and are ingested in bioreactive forms. To test whether dietary …

[HTML][HTML] Oxidative stress-inducing carbonyl compounds from common foods: novel mediators of cellular dysfunction

W Cai, Q Gao, L Zhu, M Peppa, C He, H Vlassara - Molecular medicine, 2002 - Springer
Background The general increase in reactive oxygen species generated from glucose-derived
advanced glycation endproducts (AGEs) is among the key mechanisms implicated in …