The oncoproteins MDM2 and MDMX negatively regulate the activity and stability of the tumor
suppressor protein p53, conferring tumor development and survival. Antagonists targeting …

Defensins constitute a major class of cationic antimicrobial peptides in mammals and vertebrates,
acting as effectors of innate immunity against infectious microorganisms. It is generally …

The aim of this work is to explore effects of carrageenan on sustained-release properties of
poloxamer 407-based vaginal in situ gel. After formulation of composite gel systems …

Inhibition of the interaction between the tumor suppressor protein p53 and its negative regulators
MDM2 and MDMX is of great interest in cancer biology and drug design. We previously …

Human defensins are a family of small antimicrobial proteins found predominantly in leukocytes
and epithelial cells that play important roles in the innate and adaptive immune defense …

Targeting hepatic stellate cells (HSCs) has been challenging due to the lack of specific
receptors or motifs on the cells. The aim of the present study was to develop a HSC-specific …

Despite the small size and conserved tertiary structure of defensins, little is known at a
molecular level about the basis of their functional versatility. For insight into the mechanism(s) of …

The lymphatic system has an important defensive role in the human body. The metastasis of
most tumors initially spreads through the surrounding lymphatic tissue and eventually forms …

A retro-inverso peptide is made up of d-amino acids in a reversed sequence and, when
extended, assumes a side chain topology similar to that of its parent molecule but with inverted …

The oncoprotein MDM2 negatively regulates the activity and stability of the p53 tumor
suppressor and is an important molecular target for anticancer therapy. Aided by mirror image …