The 2016 World Health Organization Classification of Tumors of the Central Nervous System
is both a conceptual and practical advance over its 2007 predecessor. For the first time, the …

The fourth edition of the World Health Organization (WHO) classification of tumours of the
central nervous system, published in 2007, lists several new entities, including angiocentric …

Malignant astrocytic gliomas such as glioblastoma are the most common and lethal
intracranial tumors. These cancers exhibit a relentless malignant progression characterized by …

The new World Health Organization (WHO) classification of nervous system tumors, published
in 2000, emerged from a 1999 international consensus conference of neuropathologists. …

Inheritance of a mutation at the Rb-1 locus, which has been mapped to band q14 of human
chromosome 13, results in predisposition to retinoblastoma. Cloned DNA segments …

This book on the World Health Organization (WHO) classification of tumours of the nervous
system reflects the view of a working group that convened for an editorial and consensus …

Background The epidermal growth factor receptor (EGFR) is frequently amplified, overexpressed,
or mutated in glioblastomas, but only 10 to 20 percent of patients have a response to …

CpG islands frequently contain gene promoters or exons 1 and are usually unmethylated in
normal cells 1, 2, 3. Methylation of CpG islands is associated with delayed replication, …

Although genetic analysis has demonstrated that members of the winged helix, or forkhead,
family of transcription factors play pivotal roles in the regulation of cellular differentiation and …

Malignant brain tumors strike deep into the psyche of those receiving and those delivering
the diagnosis. Malignant gliomas, the most common subtype of primary brain tumors, are …