Accurate determination of tumor human epidermal growth factor receptor 2 (HER2)‐status in
breast cancer patients is possible via noninvasive imaging, provided adequate tracers are …

Tumor-associated macrophages (TAM) are an important component of the tumor stroma
and exert several tumor-promoting activities. Strongly pro-angiogenic TAMs that reside in …

Nanobodies are the smallest fully functional antigen-binding antibody fragments possessing
ideal properties as probes for molecular imaging. In this study we labeled the anti–human …

RIT has become an attractive strategy in cancer treatment, but still faces important drawbacks
due to poor tumor penetration and undesirable pharmacokinetics of the targeting vehicles. …

The interplay between bone marrow stromal cells (BMSCs) and multiple myeloma (MM)
cells performs a crucial role in MM pathogenesis by secreting growth factors, cytokines, and …

Human epidermal growth factor receptor 2 (HER2) status is one of the major tumor characteristics
in breast cancer to guide therapy. Anti-HER2 treatment has clear survival advantages …

Camelidae possess an unusual class of antibodies devoid of light chains. Nanobodies are
intact antigen-binding fragments that are stable, easily generated against different targets, …

Purpose Overexpression of the epidermal growth factor receptor (EGFR) occurs with high
incidence in various carcinomas. The oncogenic expression of the receptor has been …

Rationale: A noninvasive tool allowing the detection of vulnerable atherosclerotic plaques is
highly needed. By combining nanomolar affinities and fast blood clearance, nanobodies …

Nanobodies (Nbs), the variable domains of camelid heavy chain-only antibodies, are a
promising class of therapeutics or in vivo imaging reagents entering the clinic. They possess …