Prostate cancer is the second leading cause of cancer‐related death in men. A typical feature
of this disease is its ability to metastasize to bone. It is mainly osteosclerotic, and is caused …

The use of patient-derived primary cell cultures in cancer preclinical assays has increased in
recent years. The management of resected tumor tissue remains complex and a number of …

Although the role of miR-200s in regulating E-cadherin expression and epithelial-to-mesenchymal
transition is well established, their influence on metastatic colonization remains …

Myxofibrosarcoma (MFS) is a common entity of adult soft tissue sarcomas (STS) characterized
by a predilection of the extremities and a high local recurrence rate. Originally classified …

The tumour stroma is an active participant during cancer progression. Stromal cells promote
tumour progression and metastasis through multiple mechanisms including enhancing …

The epithelial–mesenchymal transition (EMT) is a complex process that occurs during
organogenesis and in cancer metastasis. Despite recent progress, the molecular pathways …

Understanding the mechanism by which tumor cells influence osteoclast differentiation is
crucial for improving treatment of osteolytic metastasis. Here, we report broad microRNA (…

Emerging evidence suggests that cancer is populated and maintained by tumour-initiating
cells (TICs) with stem-like properties similar to those of adult tissue stem cells. Despite recent …

Background Zoledronic acid reduces skeletal-related events in patients with breast cancer,
but concerns have been raised about prolonged monthly administration. We assessed the …

Background This analysis was performed to further characterise treatment-emergent
hypocalcaemia in patients with bone metastases receiving denosumab. Methods Laboratory …