We identified in-frame fusion transcripts of KIF5B (the kinesin family 5B gene) and the RET
oncogene, which are present in 1–2% of lung adenocarcinomas (LADCs) from people from …

We carried out a multistage genome-wide association study of type 2 diabetes mellitus in
Japanese individuals, with a total of 1,612 cases and 1,424 controls and 100,000 SNPs. The …

Purpose To evaluate epidermal growth factor receptor (EGFH) mutations and copy number
as predictors of clinical outcome in patients with non-small-cell lung cancer (NSCLC) …

The overwhelming majority of participants in current genetic studies are of European ancestry.
To elucidate disease biology in the East Asian population, we conducted a genome-wide …

Background Helicobacter pylori infection is a well-known risk factor for gastric cancer. However,
the contribution of germline pathogenic variants in cancer-predisposing genes and their …

Mass productio! l and mass consumption, so far considered virtues in a free economic soceity,
have changed. Various problems have occurred including economic stagnation, energy …

Hepatocellular carcinoma, one of the most common virus-associated cancers, is the third most
frequent cause of cancer-related death worldwide 1 . By massively parallel sequencing 2 …

Gasdermin (GSDM or GSDMA), expressed in the upper gastrointestinal tract but frequently
silenced in gastric cancers (GCs), regulates apoptosis of the gastric epithelium. It has three …

Objectives SN-38, an active metabolite of irinotecan, is detoxified by glucuronidation with
UGT1A isoforms, 1A1, 1A7, 1A9, and 1A10. The pharmacogenetic information on UGT1A …

Next‐generation sequencing ( NGS ) of tumor tissue (ie, clinical sequencing) can guide
clinical management by providing information about actionable gene aberrations that have …