We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest
human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 …

The overwhelming majority of participants in current genetic studies are of European ancestry.
To elucidate disease biology in the East Asian population, we conducted a genome-wide …

We identified in-frame fusion transcripts of KIF5B (the kinesin family 5B gene) and the RET
oncogene, which are present in 1–2% of lung adenocarcinomas (LADCs) from people from …

ARID1A encodes an SWI/SNF chromatin-remodeling factor and is frequently mutated in
various cancers. This study demonstrates that ARID1A-deficient cancer cells are specifically …

The stable expansion of tissue-specific stem cells in vitro has contributed to research on several
organs. Alveolar epithelial type II (AT2) cells function as tissue stem cells in the lung, but …

Purpose Exosomal microRNAs (miRNAs) have been attracting major interest as potential
diagnostic biomarkers of cancer. The aim of this study was to characterize the miRNA profiles …

The recent discovery and characterization of an oncogenic ROS1 gene fusion in a subset of
lung cancers has raised significant clinical interest because small molecule inhibitors may …

Activation of the EGFR, KRAS, and ALK oncogenes defines 3 different pathways of molecular
pathogenesis in lung adenocarcinoma. However, many tumors lack activation of any …

The hOGG1 gene encodes a DNA glycosylase that excises 8-hydroxyguanine (oh 8 Gua)
from damaged DNA. Structural analyses of the hOGG1 gene and its transcripts were …

Background RET rearrangements are rare oncogenic alterations in non-small-cell lung cancer
(NSCLC). Vandetanib is a multitargeted tyrosine kinase inhibitor exhibiting RET kinase …