Targeting tumors with antibody-based therapeutics is a complex task presenting multiple
kinetic barriers. Antibody internalization and clearance inhibit uptake both in solid tumors, …

Li−LSX zeolite (Si/Al = 1.0) is currently the best sorbent in use in the separation of air by
adsorption processes. In this present work we have synthesized fully exchanged Li−LSX zeolite …

Objectives The objectives of this study were to determine whether differences in CYP2C8
and CYP2C9 haplotype influence the dose of ibuprofen self-administered by individuals, and …

From a purely theoretical analogy between energy and momentum transfer in fully developed
turbulent Convection, an expression without explicit empiricism, and which appears to be …

Introduction: the effects of obesity on health are a concern for the military as they affect the
fitness to serve of active service members, increase costs to the Military Health System, and …

… Administration of ODN with a high‐fat meal led to ∼100% increases in AUC 0–24 h , C
max,day1 , C max,overall and C 24 h relative to the fasted state, while administration with a low‐…

Autologous T cells transduced to express a high affinity T-cell receptor specific to NY-ESO-1
(letetresgene autoleucel, lete-cel) show promise in the treatment of metastatic synovial …

Cathepsin K (CatK) is a cysteine protease abundantly expressed by osteoclasts and localized
in the lysosomes and resorption lacunae of these cells. CatK is the principal enzyme …

Odanacatib is a selective inhibitor of the cathepsin K enzyme that is expressed in osteoclasts
involved in the degradation of bone organic matrix, and is being developed as a novel …

Purpose The purpose of this study is to characterize niraparib pharmacokinetics (PK) and
safety in patients with normal hepatic function (NHF) versus moderate hepatic impairment (MHI…