[HTML][HTML] New potential pharmacological functions of Chinese herbal medicines via regulation of autophagy

BYK Law, SWF Mok, AG Wu, CWK Lam, MXY Yu… - Molecules, 2016 - mdpi.com
Autophagy is a universal catabolic cellular process for quality control of cytoplasm and
maintenance of cellular homeostasis upon nutrient deprivation and environmental stimulus. It …

Selective inhibition of lysine‐specific demethylase 5A (KDM5A) using a rhodium (III) complex for triple‐negative breast cancer therapy

GJ Yang, W Wang, SWF Mok, C Wu… - Angewandte …, 2018 - Wiley Online Library
Lysine‐specific demethylase 5A (KDM5A) has recently become a promising target for epigenetic
therapy. In this study, we designed and synthesized metal complexes bearing ligands …

The FHL2 regulation in the transcriptional circuitry of human cancers

CY Cao, SWF Mok, VWS Cheng, SKW Tsui - Gene, 2015 - Elsevier
The Four-and-a-half LIM (FHL)-only protein is a subfamily of protein members under the LIM-only
protein family. These proteins are identified by their characteristic four and a half …

Natural products-based polypharmacological modulation of the peripheral immune system for the treatment of neuropsychiatric disorders

SWF Mok, VKW Wong, HH Lo, IRSR Dias… - Pharmacology & …, 2020 - Elsevier
Chronic inflammation of the central nervous system (CNS) is critical to the pathogenesis of
neuropsychiatric disorders (NPDs) that affect the global population. Current therapeutics for …

[HTML][HTML] Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers

BYK Law, SWF Mok, WK Chan, SW Xu, AG Wu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Drug resistance hinder most cancer chemotherapies and leads to disease recurrence and
poor survival of patients. Resistance of cancer cells towards apoptosis is the major cause of …

An anti-prostate cancer benzofuran-conjugated iridium (III) complex as a dual inhibitor of STAT3 and NF-κB

…, W Wang, HJ Zhong, ZZ Dong, Q Huang, SWF Mok… - Cancer letters, 2017 - Elsevier
Four benzofuran-conjugated iridium(III) or rhodium (III)-based metal complexes are synthesized
to screen as an inhibitor of STAT3 activity in prostate cancer cells. All complexes show …

Ca2+ signalling plays a role in celastrol‐mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats

…, TW Chan, Y Han, N Zhang, SWF Mok… - British journal of …, 2019 - Wiley Online Library
Background and Purpose Celastrol exhibits anti‐arthritic effects in rheumatoid arthritis (RA),
but the role of celastrol‐mediated Ca 2+ mobilization in treatment of RA remains undefined. …

[HTML][HTML] Neferine induces autophagy-dependent cell death in apoptosis-resistant cancers via ryanodine receptor and Ca2+-dependent mechanism

…, F Michelangeli, YQ Qu, SW Xu, Y Han, SWF Mok… - Scientific reports, 2019 - nature.com
Resistance of cancer cells to chemotherapy is a significant clinical concern and mechanisms
regulating cell death in cancer therapy, including apoptosis, autophagy or necrosis, have …

The short-chain fatty acid butyrate accelerates vascular calcification via regulation of histone deacetylases and NF-κB signaling

H Zhong, H Yu, J Chen, SWF Mok, X Tan, B Zhao… - Vascular …, 2022 - Elsevier
Recent studies have shown that short-chain fatty acids (SCFAs), primarily acetate, propionate
and butyrate, play a crucial role in the pathogenesis of cardiovascular disease. Whether …

SERCA and P-glycoprotein inhibition and ATP depletion are necessary for celastrol-induced autophagic cell death and collateral sensitivity in multidrug-resistant …

…, J Chen, W Zhang, JR Guo, AG Wu, SWF Mok… - Pharmacological …, 2020 - Elsevier
Multidrug resistance (MDR) represents an obstacle in anti-cancer therapy. MDR is caused
by multiple mechanisms, involving ATP-binding cassette (ABC) transporters such as P-…