Pancreatic ductal adenocarcinoma (PDAC) is among the most devastating human malignancies.
The poor clinical outcome in PDAC is partly attributed to a growth-permissive tumor …

Background Carcinoembryonic antigen (CEA) is one of the most widely used tumor markers
and is increased in 30%–60% of patients with pancreatic cancer. Although carbohydrate …

Objective Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive type of GI
tumour, and it possesses deregulated cellular energetics. Although recent advances in PDAC …

FBW7 functions as a tumor suppressor by targeting oncoproteins for degradation. Our previous
study found FBW7 was low expressed in pancreatic cancer due to sustained activation of …

Pancreatic cancer is an aggressive and devastating disease that is characterized by
uncontrolled progression, invasiveness and resistance to conventional treatment. In the past …

F-box and WD repeat domain-containing 7 (FBW7) is the substrate recognition component
of the Skp1-Cul1-F-box (SCF) ubiquitin ligase complex and functions as a major tumor …

UHRF1 (ubiquitin like with plant homeodomain and ring finger domains 1) is an epigenetic
modifier that is overexpressed in some cancers, including pancreatic cancer, and mediates …

ADP Ribosylation Factor 6 (ARF6) is a part of the RAS superfamily and regulates vesicular
trafficking, remodeling of membrane lipids, and signaling pathways. Our previous study has …

Ferroptosis is a recently defined, non‐apoptotic, regulated cell death (RCD) process that
comprises abnormal metabolism of cellular lipid oxides catalysed by iron ions or iron‐…

Background The epigenetic factor protein arginine methyltransferase 5 (PRMT5) has been
reported to play vital roles in a wide range of cellular processes, such as gene transcription, …