Non-receptor and receptor tyrosine kinases, such as Src and EGF receptor (EGFR), are major
inducers of vascular endothelial growth factor (VEGF), one of the most potent mediators of …

Although tumor progression involves processes such as tissue invasion that can activate
inflammatory responses, the immune system largely ignores or tolerates disseminated cancers. …

The immune system can act as an extrinsic suppressor of tumors. Therefore, tumor progression
depends in part on mechanisms that downmodulate intrinsic immune surveillance. …

Results of case‐control studies and of a prospective investigation in men suggest that
consumption of coffee could protect against the risk of Parkinson's disease, but the active …

Background Obesity and asthma are common disorders, and their prevalence rates continue
to rise. Although individuals with asthma may gain weight as a result of activity limitations, …

ContextInconsistent findings from observational studies have continued the controversy
over the effects of dietary fiber on colorectal cancer.ObjectiveTo evaluate the association …

S3I-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity, which was identified from
the National Cancer Institute chemical libraries by using structure-based virtual screening …

Background Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce dopaminergic neuron
degeneration in animal models of Parkinson disease (PD). However, no epidemiological data …

Background Reports of multiple sclerosis developing after hepatitis B vaccination have led
to the concern that this vaccine might be a cause of multiple sclerosis in previously healthy …

Data from laboratory studies, observational research, and/or secondary prevention trials
suggest that vitamin D and marine omega-3 fatty acids may reduce risk for cancer or …