This work demonstrated that ultrasmall gold nanoparticles (AuNPs) smaller than 10 nm display
unique advantages over nanoparticles larger than 10 nm in terms of localization to, and …

Mitochondrial redox homeostasis, the balance between reactive oxygen species and
antioxidants such as glutathione, plays critical roles in many biological processes, including …

A new type of metabolizable and efficient radiosensitizers for cancer radiotherapy is
presented by combining ultrasmall Au nanoclusters (NCs, <2 nm) with biocompatible coating …

The aim of this study was to determine the size-dependent penetration ability of gold nanoparticles
and the potential application of ultrasmall gold nanoparticles for intranucleus delivery …

Correlation of the surface physicochemical properties of nanoparticles with their interactions
with biosystems provides key foundational data for nanomedicine. We report here the …

Drug resistance and toxicity constitute challenging hurdles for cancer therapy. The application
of nanotechnology for anticancer drug delivery is expected to address these issues and …

Cancer vaccines hold great promise for improved cancer treatment. However, endosomal
trapping and low immunogenicity of tumour antigens usually limit the efficiency of vaccination …

Nanoparticles offer potential as drug delivery systems for chemotherapeutics based on
certain advantages of molecular drugs. In this study, we report that particle size exerts great …

Pharmaceutical drug therapy is often hindered by issues caused by poor drug selectivity,
including unwanted side effects and drug resistance. Spatial and temporal control over drug …

Traditional chemotherapy suffers from severe toxicity and side effects that limit its maximum
application in cancer therapy. To overcome this challenge, an ideal treatment strategy would …