Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not
been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea…

Calorie restriction (CR) and fasting are common approaches to weight reduction, but the
maintenance is difficult after resuming food consumption. Meanwhile, the gut microbiome …

Hyocholic acid (HCA) and its derivatives are found in trace amounts in human blood but
constitute approximately 76% of the bile acid (BA) pool in pigs, a species known for its …

Background The composition of the bile acid (BA) pool is closely associated with obesity
and is modified by gut microbiota. Perturbations of gut microbiota shape the BA composition, …

Non-alcoholic fatty liver disease (NAFLD) is regarded as a pandemic that affects about a
quarter of the global population. Recently, host-gut microbiota metabolic interactions have …

BACKGROUND: Cilostazol has been widely used to prevent peripheral vascular events,
and its antiplatelet mechanisms may different from aspirin and clopidogrel. We hypothesized …

Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known
for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA …

There are three major dendritic cell (DC) subsets in both humans and mice, that is,
plasmacytoid DCs and two types of conventional DCs (cDCs), cDC1s and cDC2s. cDC2s are …

Inflammatory cells and mediators form a major part of the tumor microenvironment and play
important roles in the regulation of cancer initiation, tumor cell proliferation, and metastasis. …

The development of effective therapies for the prevention of colorectal cancer (CRC) liver
metastasis is of great importance. Recently, chitosan (CS) nanoparticles have been utilized as …