RNA folding is a remarkably complex problem that involves ion-mediated electrostatic
interaction, conformational entropy, base pairing and stacking, and noncanonical interactions. …

In addition to continuous rapid progress in RNA structure determination, probing, and biophysical
studies, the past decade has seen remarkable advances in the development of a new …

With rapid advances in computer algorithms and hardware, fast and accurate virtual screening
has led to a drastic acceleration in selecting potent small molecules as drug candidates. …

Metal ions play crucial roles in thermal stability and folding kinetics of nucleic acids. For ions
(especially multivalent ions) in the close vicinity of nucleic acid surface, interion correlations …

Aims Observational studies have suggested strong associations between sleep duration and
many cardiovascular diseases (CVDs), but causal inferences have not been confirmed. We …

In concurrent engineering, project tasks generally involve the establishment of multifunctional
design teams in order to simultaneously consider various activities throughout the entire …

We report the results of a first, collective, blind experiment in RNA three-dimensional (3D)
structure prediction, encompassing three prediction puzzles. The goals are to assess the …

Protein fold prediction using deep-learning artificial intelligence (AI) has transformed the
field of protein structure prediction (1–3). By combining physical and geometric constraints—…

Adeno-associated virus (AAV)-mediated CRISPR-Cas9 editing holds promise to treat many
diseases. The immune response to bacterial-derived Cas9 has been speculated as a hurdle …

Using a statistical mechanical treatment, we study RNA folding energy landscapes. We first
validate the theory by showing that, for the RNA molecules we tested having only secondary …