[HTML][HTML] PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin β1-ERK1/2 and-MMP2 signaling
L Peng, X Xing, W Li, L Qu, L Meng, S Lian, B Jiang… - Molecular cancer, 2009 - Springer
Background Phosphatase of regenerating liver-3 (PRL-3) plays a causative role in tumor
metastasis, but the underlying mechanisms are not well understood. In our previous study, we …
metastasis, but the underlying mechanisms are not well understood. In our previous study, we …
[HTML][HTML] FOXM1 functions collaboratively with PLAU to promote gastric cancer progression
C Ai, J Zhang, S Lian, J Ma, B Győrffy, Z Qian… - Journal of …, 2020 - ncbi.nlm.nih.gov
Background: Gastric cancer (GC) is one of the main mortality cause worldwide. Previously,
we found Forkhead box protein (FOXM1) or Urokinase-type plasminogen activator (PLAU) …
we found Forkhead box protein (FOXM1) or Urokinase-type plasminogen activator (PLAU) …
Targeted genome fragmentation with CRISPR/Cas9 enables fast and efficient enrichment of small genomic regions and ultra-accurate sequencing with low DNA input …
D Nachmanson, S Lian, EK Schmidt, MJ Hipp… - Genome …, 2018 - genome.cshlp.org
Next-generation sequencing methods suffer from low recovery, uneven coverage, and false
mutations. DNA fragmentation by sonication is a major contributor to these problems …
mutations. DNA fragmentation by sonication is a major contributor to these problems …
[HTML][HTML] Phosphatase of regenerating liver-3 (PRL-3) is associated with metastasis and poor prognosis in gastric carcinoma
X Xing, S Lian, Y Hu, Z Li, L Zhang, X Wen… - Journal of translational …, 2013 - Springer
Background PRL-3 is a member of phosphatases of regenerating liver family, characterized
by phosphatase active domain and C-terminal prenylation motif. Overexpression of PRL-3 …
by phosphatase active domain and C-terminal prenylation motif. Overexpression of PRL-3 …
PRL-3 promotes ubiquitination and degradation of AURKA and colorectal cancer progression via dephosphorylation of FZR1
C Zhang, L Qu, S Lian, L Meng, L Min, J Liu, Q Song… - Cancer research, 2019 - AACR
Dephosphorylation of FZR1 by PRL-3 facilitates the activity of APC/C FZR1 by destabilizing
AURKA, thus influencing aggressive characteristics and overall progression of colorectal …
AURKA, thus influencing aggressive characteristics and overall progression of colorectal …
[HTML][HTML] PTP4A3 is a prognostic biomarker correlated with immune infiltrates in papillary renal cell carcinoma
…, J Wu, S Wang, L Meng, Q Yao, Z Li, S Lian - Frontiers in …, 2021 - frontiersin.org
PTP4A3 plays an important role in the tumorigenesis and metastasis of multiple tumors, but
its prognostic role in renal cancer is not well understood. We utilized the Oncomine and …
its prognostic role in renal cancer is not well understood. We utilized the Oncomine and …
PRL-3 activates NF-κB signaling pathway by interacting with RAP1
S Lian, L Meng, C Liu, X Xing, Q Song, B Dong… - Biochemical and …, 2013 - Elsevier
Phosphatase of regenerating liver (PRL-3) promotes cancer metastasis through enhanced
cell motility and invasiveness, however its role in tumorigenesis remains unclear. Herein, we …
cell motility and invasiveness, however its role in tumorigenesis remains unclear. Herein, we …
PRL-3 promotes telomere deprotection and chromosomal instability
S Lian, L Meng, Y Yang, T Ma, X Xing… - Nucleic acids …, 2017 - academic.oup.com
Phosphatase of regenerating liver (PRL-3) promotes cell invasiveness, but its role in genomic
integrity remains unknown. We report here that shelterin component RAP1 mediates …
integrity remains unknown. We report here that shelterin component RAP1 mediates …
[HTML][HTML] Antibody array revealed PRL-3 affects protein phosphorylation and cytokine secretion
Y Yang, S Lian, L Meng, L Qu, C Shou - PloS one, 2017 - journals.plos.org
Phosphatase of regenerating liver 3 (PRL-3) promotes cancer metastasis and progression
via increasing cell motility and invasiveness, however the mechanism is still not fully …
via increasing cell motility and invasiveness, however the mechanism is still not fully …
Unconventional secretion of synuclein‐γ promotes tumor cell invasion
C Liu, L Qu, S Lian, Z Tian, C Zhao, L Meng… - The FEBS …, 2014 - Wiley Online Library
Synuclein‐γ ( SNCG ) is a chaperone protein and exists mainly in the cytoplasm. SNCG
confers chemoresistance, and is a potential unfavorable biomarker for multiple types of cancer. …
confers chemoresistance, and is a potential unfavorable biomarker for multiple types of cancer. …