There are innumerable anticancer compounds derived from either natural or synthetic origins.
Many of these compounds have been further developed through structural modifications …

Objective: Anoikis is apoptosis that is induced when cells detach from the extracellular matrix
and neighboring cells. As anoikis serves as a regulatory barrier, cancer cells often acquire …

Dysregulation of microRNAs (miRNAs) has been implicated in almost every known survival
mechanisms utilized by cancer cells. One of such mechanisms, anoikis resistance, plays a …

1′-acetoxychavicol acetate (ACA) extracted from the rhizomes of Alpinia conchigera Griff (Zingiberaceae)
has been shown to deregulate the NF-ĸB signaling pathway and induce …

Cancer development and progression are extremely complex due to the alteration of
various genes and pathways. In most cases, multiple agents are required to control cancer …

Geranylated 4-phenylcoumarins DMDP-1 and DMDP-2 isolated from Mesua elegans were
elucidated for their role in inducing caspase-independent programmed cell death (CI-PCD) in …

Anoikis is apoptosis induced when cells are detached from the extracellular matrix and
neighbouring cells. Since anoikis serves as a regulatory barrier, cancer cells often acquire …

Anoikis is apoptosis induced when cells are detached from the extracellular matrix and
neighbouring cells. Since anoikis serves as a regulatory barrier, cancer cells often acquire …

… Sharan Malagobadan for his close guidance and help throughout my study and in the
process of this writing. Not to forget, Dr. Dennise Ho and Dr. …

… I would like to extend my gratitude to my colleague and lab mate Dr Sharan Malagobadan
for his support in proofreading the thesis. I would also like to thank my lab mates Mahmudul, …