Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours: a multicentre, open-label, randomised controlled trial

…, J Ke, F Feng, B Chen, X Yin, W Chen… - The lancet …, 2021 - thelancet.com
Background The benefit and safety of laparoscopic pancreatoduodenectomy (LPD) for the
treatment of pancreatic or periampullary tumours remain controversial. Studies have shown …

[HTML][HTML] Excessive miR-25-3p maturation via N6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression

…, X Che, D Xie, W Jia, MS Zeng, W Tan, R Chen… - Nature …, 2019 - nature.com
N 6 -methyladenosine (m 6 A) modification is an important mechanism in miRNA processing
and maturation, but the role of its aberrant regulation in human diseases remained unclear. …

[HTML][HTML] Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer

C Chen, Y Luo, W He, Y Zhao, Y Kong… - The Journal of …, 2020 - Am Soc Clin Investig
Patients with bladder cancer (BCa) with clinical lymph node (LN) metastasis have an extremely
poor prognosis. VEGF-C has been demonstrated to play vital roles in LN metastasis in …

Long non‐coding RNA cox‐2 prevents immune evasion and metastasis of hepatocellular carcinoma by altering M1/M2 macrophage polarization

…, Y Li, R Wang, X Luo, R Chen, T Chen - Journal of cellular …, 2018 - Wiley Online Library
Macrophages have been shown to demonstrate a high level of plasticity, with the ability to
undergo dynamic transition between M1 and M2 polarized phenotypes. We investigate long …

[HTML][HTML] The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer

…, H Chen, W Li, H Li, H Li, Z Fu, R Chen - Journal of translational …, 2015 - Springer
Background The human genome encodes many long non-coding RNAs (lncRNAs). However,
their biological functions, molecular mechanisms, and the prognostic value associated …

[HTML][HTML] circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer

…, J Zhu, H Zheng, B Gao, X Guo, Z Li, R Chen, C Chen - Molecular Cancer, 2020 - Springer
Background Patients with lymph node (LN)-positive pancreatic ductal adenocarcinoma (PDAC)
have extremely poor survival rates. Circular RNAs (circRNAs), a newly discovered type …

[HTML][HTML] Tumor-associated macrophages promote progression and the Warburg effect via CCL18/NF-kB/VCAM-1 pathway in pancreatic ductal adenocarcinoma

…, Q Lin, L Wei, Z Fu, B Zhang, Y Liu, Z Li, R Chen - Cell death & …, 2018 - nature.com
Tumor-associated macrophages (TAMs) are frequently found near pancreatic cancer cells,
but it is uncertain whether they are involved in pancreatic cancer progression and the …

[HTML][HTML] LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9

Z Fu, C Chen, Q Zhou, Y Wang, Y Zhao, X Zhao, W Li… - Cancer letters, 2017 - Elsevier
Our previous study demonstrated that long non-coding RNA (lncRNA) HOTTIP was maximally
expressed in PDAC, and promoted cancer cell progression and epithelial to mesenchymal …

Practice patterns and perioperative outcomes of laparoscopic pancreaticoduodenectomy in China: a retrospective multicenter analysis of 1029 patients

…, Z Tan, R Liu, D Hong, W Zhao, H Wu, R Chen… - Annals of …, 2021 - journals.lww.com
Objective: The aim of the study was to analyze the outcomes of patients who have undergone
laparoscopic pancreaticoduodenectomy (LPD) in China. Summary Background Data: LPD …

Linc00511 acts as a competing endogenous RNA to regulate VEGFA expression through sponging hsa‐miR‐29b‐3p in pancreatic ductal adenocarcinoma

…, L Li, Y Jiang, Y Luo, Q Lin, Z Fu, C Rufu - Journal of cellular …, 2018 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy. Long non‐coding RNAs (lncRNAs)
are important regulators in pathological processes, yet their potential roles in …